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Infliximab does not increase the risk of early postoperative complications in UC patients after a three-stage restorative proctocolectomy with IPAA


Authors: M. Kostrejová 1;  M. Bortlík 2,3;  M. Lukáš 2,4;  D. Ďuricová 2,5;  R. Mudr 1;  A. Komárek 6;  R. Sequens 1
Authors‘ workplace: Gastroenterologické oddělení, Nemocnice Milosrdných sester sv. Karla Boromejského, Praha 1;  Klinické a výzkumné centrum pro střevní záněty ISCARE I. V. F. a. s. a 1. LF UK, Praha 2;  Interní klinika 1. LF UK a ÚVN, Praha 3;  Ústav lékařské biochemie a laboratorní diagnostiky, 1. LF UK a VFN, Praha 4;  Ústav farmakologie, 1. LF UK, Praha 5;  Katedra pravděpodobnosti a matematické statistiky MFF UK, Praha 6
Published in: Gastroent Hepatol 2014; 68(1): 14-18
Category: IDB: Original Article

Overview

Introduction and aim:
Patients with ulcerative colitis (UC) treated with infliximab (IFX) preoperatively are theoretically at increased risk of complications after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA). The aim was to compare the occurrence of early postoperative complications among patients treated and not treated with IFX.

Methods:
A retrospective analysis of different types of early postoperative complications in UC patients treated and not treated with IFX.

Results:
Between January 2006 and December 2012, 138 UC patients underwent surgical therapy. Of these patients, 108 had restorative proctocolectomy and IPAA. Forty-seven patients received IFX preoperatively (IFX group), while 61 did not receive any IFX (No-IFX group). In total, early complications occurred in 40.4% of patients in the IFX group, and in 44.3% in the No-IFX group. Using logistic regression analysis, no statistically significant difference was found in the occurrence of any particular type of both surgical and non-surgical complications.

Conclusion:
We did not observe an increased occurrence of early postoperative complications in UC patients after a three-stage restorative proctocolectomy with IPAA.

Key words:
ulcerative colitis – infliximab – restorative proctocolectomy – postoperative complications

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
17. 1. 2014

Accepted:
3. 2. 2014


Sources

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Labels
Paediatric gastroenterology Gastroenterology and hepatology Surgery

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Gastroenterology and Hepatology

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2014 Issue 1

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