Ulcerative colitis complicated by tromboembolism and toxic megacolon – is there any connection between toxic megacolon and anticoagulative therapy?

Czech version

Authors: D. Mokrá ¹; J. Háša ¹; J. Masopust ¹; O. Hloch ¹; J. Charvát ¹; J. Drábek ¹; J. Šťovíček ¹; J. Chudý ¹; Š. Hlava ¹; R. Keil ¹; P. Hladík ²
Authors‘ workplace: Interní klinika 2. LF UK a FN v Motole, Praha ¹; III. chirurgická klinika 1. LF UK a FN v Motole, Praha ²
Published in: Gastroent Hepatol 2013; 67(4): 313-316
Category: Clinical and Experimental Gastroenterology: Case Report

Overview

We present the case of 50-year-old man who was admitted to our hospital with exacerbation of ulcerative colitis with diarrhea and enterorrhagia. During hospitalisation the patient developed deep vein trombosis of lower extremity with consequential pulmonary embolism requiring anticoagulation therapy (unfractionated heparin). A toxic megacolon did not respond to rescue with infliximab therapy, and therefore colectomy was performed.

Key words:
heparin – toxic megacolon – tromboembolism – ulcerative colitis

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
21. 6. 2013

Accepted:
14. 7. 2013

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