Perspectives in the treatment of dyslipoproteinemias in diabetes

Czech version

Authors: Ivan Tkáč
Authors‘ workplace: IV. interná klinika UPJŠ LF a UNLP Košice
Published in: Forum Diab 2019; 8(2): 80-83
Category: Review Article

Overview

Hyperlipoproteinemias characterized by elevated LDL cholesterol (LDL-C), triglycerides or lipoprotein(a) have been shown to be pathogenetic risk factors for atherosclerosis. This is based on prospective epidemiological studies of cohorts, as well as recent studies of mendelian randomization.

Treatment to reduce LDL-C levels by using statins, ezitimibe, or PCSK9 inhibitors has led to a reduction in the risk of developing cardiovascular events in the frame of secondary prevention and has been shown to be beneficial in type 2 diabetes because of its significant cardiovascular risk. Treatment increasing HDL-cholesterol (HDL-C) has not been proven to prevent cardiovascular events. New drugs are being developed that can reduce triglycerida and lipoprotein(a) levels more significantly than the currently used lipid-lowering drugs. Their wider use could contribute to a greater reduction in residual cardiovascular risk in diabetic patients in the near future.

Keywords:

LDL-cholesterol – hyperlipidemia – lipoprotein(a) – mendelian randomization – triglycerides

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