Vliv glukokortikoidového receptoru na hyperpyrexii navozenou metamfetaminem
Authors:
S. Yoshida 1; H. Kinoshita 2; T. Tatara 1; C. Tashiro 1; M. Nishiguchi 3; H. Ouchi 3; T. Minami 3; S. Hishida 3
Authors‘ workplace:
Department of Anesthesia, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 66 -8501, Japan
1; Department of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki, Kita, Kagawa, 761-079 , Japan
2; Department of Legal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan
3
Published in:
Soud Lék., 57, 2012, No. 4, p. 66-68
Category:
Original Article
Overview
Byl zkoumán vliv glukokortikoidu na metamfetaminem (MA) navozenou hyperpyrexii
s užitím bio-telemetrického systému. Prokazatelná úroveň hyperpyrexie byla pozorována u krys, kterým byl podáván MA. Naproti tomu vzestup tělesné teploty byl potlačen adrenalektomií nebo podáváním RU-486, tj. antagonisty glukokortikoidového receptoru. Tyto údaje nasvědčují, že glukokortokoidový receptor může být odpovědný za hyperpyrexii navozenou metamfetaminem.
Klíčová slova:
metamfetamin – hyperpyrexie – glukokortikoidy – kortikosteron
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Labels
Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Forensic Medicine
2012 Issue 4
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