#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Pitva při otravě četnými psychotropními léky


: Naoko Tanaka 1;  Hiroshi Kinoshita 1;  Minori Nishiguchi 2;  Mostofa Jamal 1;  Mitsuru Kumihashi 1;  Motonori Takahashi 2;  Hajime Nishio 2;  Kiyoshi Ameno 1
: Department of Forensic Medicine, Faculty of Medicine, Kagawa University, Japan 1;  Department of Legal Medicine, Hyogo College of Medicine, Japan 2
: Soud Lék., 56, 2011, No. 3, p. 38-39
: Original Article

Prezentován je případ smrtící otravy etizolamem, phenobarbitalem, promethazinem a chlorpromazinem. Kvantitativní toxikologická analýza prokázala, že koncentrace v krvi odebrané ze stehenní žíly dosahovala u etizolamu 86 ng/ml, phenobarbitalu 5,082 μg/ml, promethazinu 0,107 μg/ml a chlorpromazinu 0,144 μg/ml, přičemž velké množství léků bylo také zjištěno v obsahu žaludku. Uzavřeli jsme, že příčina smrti byla v souvislosti se vzájemným působením četných psychotropních léků.

Klíčová slova:
četné léky – otrava – vysokoúčinná kapalinová chromatografie – etizolam – phenobarbital


Sources

1. Baselt RC. Etizolam. In: Baselt RC, ed. Disposition of toxic drugs and chemicals in man, (8th ed). Foster City, CA: Biochemical Publications; 2008: 586–588.

2. Terada M, Yamazaki M, Honda K, Wakasugi C. A fatal etizolam poisoning. Nihon Hoigaku Zasshi 1995; 49 Suppl: 198.

3. Baselt RC. Phenobarbital. In: Baselt RC, ed. Disposition of toxic drugs and chemicals in man, (8th ed). Foster City, CA: Biochemical Publications; 2008: 1236-1238.

4. Charney DS, Mihic SJ, Harris RA. Hypnotics and sedatives. In: Brunton LL, Lazo JS, Parker KL, eds. Goodman & Gilman’s The pharmacological basis of therapeutics (11th ed). New York: McGraw-Hill; 2006: 401–427.

5. Baselt RC. Promethazine. In: Baselt RC, ed. Disposition of toxic drugs and chemicals in man, (8th ed). Foster City, CA: Biochemical Publications; 2008: 1316–1318.

6. Baselt RC. Chlorpromazine. In: Baselt RC, ed. Disposition of toxic drugs and chemicals in man, (8th ed). Foster City, CA: Biochemical Publications; 2008: 291–294.

7. Kinoshita H, Taniguchi T, Kubota A, et al. An autopsy case of imipramine poisoning. Am J Forensic Med Pathol 2005; 26: 271–274.

8. Fracasso C, Confalonieri S, Garattini S, Caccia S. Single and multiple dose pharmacokinetics of etizolam in healthy subjects. Eur J Clin Pharmacol 1991; 40: 181–185.

9. Stead AH, Moffat AC. Interpretation of therapeutic, toxic and fatal phenobarbitone blood concentrations by the use of concentration-response and toxicity probability curves. J Forens Sci Soc 1982; 22: 47–56.

10. Stead AH, Hook W, Moffat AC, Berry D. Therapeutic, toxic and fatal blood concentration ranges of antiepileptic drugs as an aid to the interpretation of analytical data. Hum Toxicol 1983; 2: 135–147.

11. Takayasu T, Kondo T. A review of fatal cases due to drugs and poisons: Medicines. Japanse Journal of Forensic Pathology 2009; 15: 21–36.

12. Winek CL, Wahba WW, Winek CL Jr, Balzer TW. Drug and chemical blood-level data 2001. Forensic Sci Int 2001; 122: 107–123.

13. Kinoshita H, Nishiguchi M, Kasuda S, et al. Forensic toxicological implication of an autopsy case of mixed drug overdose involving clomipramine, chlorpromazine and flunitrazepam. Soud Lek 2008; 53: 28–30.

14. Moffat AC, Osselton MD, Widdop B, eds. Chlorpromazine. In: Clark’s analysis of drug and poisons (3rd ed). London, Chicago: Pharmaceutical Press; 2004: 791–792.

15. Moffat AC, Osselton MD, Widdop B, eds. Etizolam. In: Clark’s analysis of drug and poisons (3rd ed). London, Chicago: Pharmaceutical Press; 2004: 1006.

16. Moffat AC, Osselton MD, Widdop B, eds. Phenobarbital. In: Clark’s analysis of drug and poisons (3rd ed). London, Chicago: Pharmaceutical Press; 2004: 1431–1432.

17. Moffat AC, Osselton MD, Widdop B, eds. Promethazine. In: Clark’s analysis of drug and poisons (3rd ed). London, Chicago: Pharmaceutical Press; 2004: 1488–1489.

Labels
Anatomical pathology Forensic medical examiner Toxicology
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#