Botulism – a rare but still present, life-threatening disease
Authors:
H. Ambrožová
Authors‘ workplace:
Klinika infekčních nemocí 2. LF UK a Nemocnice Na Bulovce, Praha
Published in:
Epidemiol. Mikrobiol. Imunol. 68, 2019, č. 1, s. 33-38
Category:
Review Article
Overview
Botulism caused by toxins of Clostridium botulinum and other neurotoxic clostridia is a rare but life-threatening disease with neurological symptoms. Food-borne botulism (food poisoning) is the most common type worldwide; rarely, wound botulism, infant botulism, or botulism of unknown etiology may also occur. Botulism is a very rare disease in the Czech Republic as well, with only nine cases reported since 2008 (EPIDAT). These were mostly sporadic cases of food-borne botulism except a small family outbreak with three cases due to the consumption of homemade pork pate (2013). This outbreak prompted the creation of a national standby supply of life-saving anti-infective drugs in Prague. This article reviews the etiology, epidemiology, clinical manifestations, diagnosis, and therapy of botulism.
Keywords:
diagnosis – Botulism – Clostridium botulinum – clinical picture
Sources
1. Adalja AA, Toner E, Inglesby TV. Clinical management of potential bioterrorism – related conditions. N Engl J Med, 2015;372:954–962.
2. Hodowanec A, Bleck TP. Botulism (Clostridium botulinum) in Mandell, Douglas, and Bennett´s Principles and Practice of Infectious Diseases. Elsevier Saunders, Philadelphia 2015, Eight ed.; Vol. 2:2763–2767.
3. Tréhard H, Poujol I, Mazuet C, et al. A cluster of three cases of botulism due to Clostridium baratii type F, France, August 2015. Euro Surveill, 2016;21(4). doi: 10.2807/1560-7917.ES.2016.21.4.300117.
4. Dykes JK, Luquez C, Raphael BH, et al. Laboratory investigation of the First Case of Botulism caused by Clostridium butyricum Type E in the United States. J Clin Microbiol, 2015;53(10):3363–3365.
5. Moodley A, Quinlisk P, Garvey A, et al. Notes from the field: infant botulism caused by Clostridium baratii type F- Iowa, 2013. MMWR Morb Mortal Wkly Rep, 2015;64(14):4006.
6. Shelley EB, O´Rourke D, Grant K, et al. Infant botulism due to C. butyricum type E toxin: a novel environmental association with pet terrapins. Epidemiol Infect, 2015;143(3):461–469.
7. Lafuente S, Barasah JR, Aron SS. A Novel Strain of Clostridium botulinum that Produces Type B and type H Botulinum Toxins. J Infect Dis, 2014;209(2):183–191.
8. Anza I, Skarin H, Vidal D, et al. The same clade of Clostridium botulinum strains is causing avian botulism in southern and northern Europe. Anaerobe, 2014;26:20–23.
9. Krüger M, Neuhaus J, Herrenthey AG, et al. Chronic botulism in a Saxony dairy farm: sources, predisposing factors, development of the disease and treatment possibilities. Anaerobe, 2014;28:220–225.
10. Lafuente S, Nolla J, Valdezate S, et al. Two simultaneous botulism outbreaks in Barcelona: Clostridium baratii and Clostridium botulinum. Epidemiol Infect, 2013;141(9):1993–1995.
11. Zhang S, WangY,Qiu S, et al. Multilocus outbreak of foodborne botulism linked to contaminated sausage in Hebei province, China. Clin Infect Dis, 2010;51(3):322–325.
12. Foodborne botulism from home-prepared fermented tofu – California 2006. Centre for CDC MMWR Morb. Mortal Wkly Rep, 2007;56(5):96–97.
13. Meusburger S, Reichert S, Heibel S, et al. Outbreak of foodborne botulism linked to barbecue, Austria 2006. Euro Surveill, 2006;11(12):E061214.4.
14. Date K, Fagan R, Crossland, et al. Three outbreaks of foodborne botulism caused by unsafe home canning of vegetables – Ohio and Washington, 2008 and 2009. J Food Prot, 2011;74(12):2090–2096.
15. Oriot C, D´Aranda E, Castanier M, et al. One collective case of type A
foodborne botulism in Corsica. Clin Toxicol (Phila), 2011;49(8):752–754.
16. Daminelli P, De Nadai V, Bozzo G, et al. Two unliked cases of foodborne botulism in Italy at the beginnig of 2010. New Microbiol, 2011;34(3):287–290.
17. Mazuet C, Sautereau J, Legeay C. An atypical outbreak of food – borne botulism due to Clostridium botulinum types B and E from ham. J Clin Microbiol, 2015;53:722–726.
18. Williams BT, Schlein SM, Caravati EM, et al. Emergency department identification and critical care management of a Utah prison botulism outbreak. Ann Emerg Med, 2014;64(1):26–31.
19. Leclair D, Fung J, Isaac-Renton JL, et al. Foodborne botulism in Canada, 1985 – 2005. Emerg Infect Dis, 2013;19(6):961–968.
20. Fagan RP, McLaughlin JB, Castrodale LJ, et al. Endemic foodborne botulism among Alaska Native persons – Alaska, 1947–2007. Clin Infect Dis, 2010;51(3):585–592.
21. Hammer TH, Jespersen S, Kanstrup J, et al. Fatal outbreak of botulism in Greenland. J Infect Dis, 2015;47(3):190–194.
22. Momose Y, Asakura H, Kitamura M, et al. Food – borne botulism in Japan in March 2012. Int J Infect Dis, 2014;24:20–22.
23. Chmelař, D. Průkaz botulotoxinu v konzervovaných jahodách. Zprávy CEM 1998;7(10):394–395.
24. Juliao PC, Maslanka S, Dykes J, et al. National outbreak of type a foodborne botulism associated with a widely distributed commercially canned hot dog chili sauce. Clin Infect Dis, 2013;56(3):376–382.
25. Špačková M, Fabiánová K. Epidemický výskyt botulismu po konzumaci ryb na Ukrajině. Zprávy CEM, 2017;26(6-7):236.
26. Špačková M, Fabiánová K. Výskyt botulismu po konzumaci ryb v Německu a Španělsku v roce 2016 a 2017. Zprávy CEM, 2017, 26(4):152–156.
27. Newkirk RW, Hedberg CW. Rapid detection of foodborne botulism outbreaks facilitated by epidemiological linking of cases: implications for food defense and public health response. Foodborne Pathog Dis, 2012;9(2):150–155.
28. Taylor SM, Wolfe CR, Dixon TC, et al. Wound botulism complicating internal fixation of a complex radial fracture. J Clin Microbiol, 2010;48(2):650–653.
29. Davis LE, Koing MK. Wound botulism from heroin skin popping. Curr Neurol Neurosci Rep, 2008;8(6):426–428.
30. Yuan J, Inami G, Mohle – Boetani J, Vugia DJ. Reccurent wound botulism among injection drug users in California. Clin Infect Dis, 2011;52(7):862–866.
31. Reller ME, Douce RW, Maslanka SE, et al. Wound botulism acquired in the Amazonian rain forest in Ecuador. Am J Trop Med Hyg, 2006;74(4):628–631.
32. Schroeter M, Alpers K, Van Treeck U, et al. Outbreak of wound botulism in injection drug users. Epidemiol Infect, 2009;137(11):1602–1608.
33. Kalka-Moll WM, Aurbach U, Schaumann R, et al. Wound botulism in injection drug users. Emerg Inf Dis, 2007;13(6):942–943.
34. Galldiks N, Bewermeyer H, Walger P, et al. Rapid geographical clustering of wound botulism in Germany after subcutaneous and intramuscular injection of heroin. Neurocrit Care, 2007;6(1):30–34.
35. Akbulut D, Dennis J, Gent M, et al. Wound botulism in injectors of drugs: upsurge in cases in England during 2004. Euro Surveill, 2005;10(9):172–174.
36. Artin I, Björkman P, Cronquist J, et al. First case of type E wound botulism diagnosed using real-time PCR. J Clin Microbiol, 2007;45(11):3589–3594.
37. Rodolico C, Barca E, Fenicia L, et al. Wound botulism in injection drug users: a still underestimated diagnosis. Neurol Sci, 2010;31(6):825–827.
38. Mac Donald E, Arnesen TM, Brantsaeter AB, et al. Outbreak of wound botulism in people who inject drugs, Norway, October to November 2013. Euro Surveill, 2013;18(45):20630.
39. Gouveia C, Mookherjee S, Russell MS. Wound botulism presenting as a deep neck space infection. Laryngoscope, 2012;122(12):2688–2689.
40. Radšel A, Andlovic A, Neubauer D, et al. Infant botulism: First two confirmed cases in Slovenia and literature review. Eur J Pediatr Neurol, 2013;23.doi:pii:S1090–3798(13)00066-4.
41. Hoarau G, Pelloux I, Gayot A, et al. Two cases of type A infant botulism in Grenoble, France: no honey for infants. Eur J Pediatr, 2012;171(3):589–591.
42. Abdulla CO, Ayubi A, Zulfiguer F, et al. Infant botulism following honey ingestion. BMJ Case Report 2012, published online, 2012, Sep7.doi:10.1136/bcr.11.2011.5153.
43. Dertman Y, Korkeala H, Salo E, et al. Infant botulism with prolonged faecal excretion of botulinum neurotoxin and Clostridium botulinum for 7 months. Epidemiol Infect, 2013:1–5 (Epub ahead of print).
44. Krüger M, Grose-Herrenthey A, Schrödl W, et al. Visceral botulism at diary farms in Schleswig Holstein, Germany – Prevalence of Clostridium botulinum in feces of cows, in animal feeds, in feces of the farmers and in house dust. Anaerobe, 2012;18(2):221–223.
45. Kobayashi T, Haginoya K, Morimoto T, et al. A case of infant botulism infection due to consumption of untreated well-water. J Pediatr, 2014;1644(4):931–933.
46. López-Laso E, Roncero-Sánchez-Cano I, Arce- Portillo et al. Infant botulism in Andalusia (Southern Spain). Eur J Paed Neurology, 2014;18:321–326.
47. Brown N, Desai S, et al. Infantile botulism: a case report and review J. Emerg Med, 2013;45(6):842–845.
48. Koepke R, Sobel J, Arnon, SS. Global occurence of infant botu-
lism.1976-2006. Pediatrics, 2008;122:e73–e82.
49. Šrámková L, Vaništa. Botulismus. Therapie der Gegenwarth: Monatsschrift für praktische Medizin, 1967;106(3):361–362.
50. Šrámová H, Beneš J. Výskyt botulismu v České republice v období 1990–1998. Prakt Lék, 1999;79(5):260–263.
51. Šrámová H, Beneš Č. Výskyt botulismu v České republice. Zprávy CEM, 1998;7(10):395–397.
52. Šrámová J, Beneš Č. Výskyt botulismu v České republice. Medica revue, 1998;5(5):18–19.
53. Šrámová H, Beneš Č. Botulimus v České republice. Čas Lék Čes, 1991;130(4):103–107.
54. Lasovská J, Závadová M, Doutlík S, Vaništa J. Neobvyklý průběh botulismu vyvolaného botulotoxinem typu E. Prakt Lék, 1983;63(1):12–13.
55. Neubauer M, Miláček V. Kojenecký botulismus. Českoslov Ped, 1981;36(9):527–529.
56. Ambrožová H, Džupová O, Smíšková D, Roháčová H. Familiární výskyt botulismu – kazuistika. Klin Mik Inf Lék, 2014;20(2):40–42.
57. Ambrožová H, Smíšková D. Botulismus – co nového? Kazuistika dalšího případu botulismu na infekční klinice Nemocnice Na Bulovce. Klin Mik Inf Lék, 2015, 21(3). (Kongres klinické mikrobiologie, infekčních nemocí a epidemiologie – KMINE 2015. Špindlerův Mlýn, 23.–25. září 2015), s. 104.
58. Chertow DS, Tan ET, Maslanka SE, et al. Botulism in 4 adults following cosmetic injections with an unlicensed, highly concentrated botulinum preparation. JAMA, 2006;296:2476–2479.
59. Ha JC, Richman DP. Myasthenia gravis and related disorders: Pathology and molecular pathogenesis. Biochem Biophys Acta;1852(4):651–657.
60. Centers for Disease Control and Prevention. Investigational heptavalent botulinum antitoxin (HBAT) to replace licensed botulinum antitoxin AB and investigational botulinum antitoxin E. MMWR Morb Mortal Wkly, 2010;59:299.
61. Arnon SS, Schechter R, Maslanka SE, et al. Human botulism immnune globulin for the treatment of infant botulism. N Engl J Med, 2006;354:462–464.
Labels
Hygiene and epidemiology Medical virology Clinical microbiologyArticle was published in
Epidemiology, Microbiology, Immunology
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