Intravenous and Subcutaneous Immunoglobulin Therapy

Czech version

Authors: Thon Vojtěch
Authors‘ workplace: Ústav klinické imunologie a alergologie, Lékařská fakulta Masarykovy univerzity a FN u sv. Anny v Brně
Published in: Epidemiol. Mikrobiol. Imunol. 62, 2013, č. 2, s. 64-73

Overview

Patients with agammaglobulinaemia and hypogammaglobulinaemia require immunoglobulin G (IgG) replacement therapy to prevent serious infections. Since the 1950s, therapy with human immune globulin products has been the standard of treatment. Currently, the most common routes of administration of IgG replacement therapy are intravenous (IVIG) or subcutaneous (SCIG). The home therapy may improve the quality of life in patients who require lifelong IgG replacement. The anti-IgA antibody test identifies the patients with the risk of anaphylactoid reactions in IVIG replacement. The SCIG delivery may be used in patients with anti-IgA antibodies and previous systemic reactions to IVIG.

Keywords:
IVIG – SCIG – immunodeficiency – immunoglobulin – anti-IgA antibodies

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Article was published in

Epidemiology, Microbiology, Immunology

2013 Issue 2