Serum Anti-Endomysium Antibodies (AEA) in the Diagnostic Algorithm of Coeliac Disease
Authors:
P. Makovický
Authors‘ workplace:
Czech University of Life Sciences, Praha
Published in:
Epidemiol. Mikrobiol. Imunol. 58, 2009, č. 4, s. 163-166
Overview
The diagnostic relevance of serum anti-endomysium antibodies (AEA) in patients with celiac disease is discussed. A group of 23 newly diagnosed patients, i.e. seven patients with mild AEA positivity (+), nine patients with intermediate AEA positivity (++) and seven patients with strong AEA positivity (+++), was selected. The AEA reactivity was evaluated semiquantitatively. Celiac disease and AEA are less than 100% correlated. The final diagnosis has to be confirmed by histopathology of small intestine biopsy specimens. The available targeted screening is an alternative with a potential for the detection of atypical forms of celiac disease. Another alternative for early diagnosis is the detection of intraepithelial lymphocyte activity or of lymphocyte mediators.
Key words:
apoptosis – gluten-free diet – diagnostics – gluten – malabsorption syndrome – small bowel – tissue transglutaminase – TNF family.
Sources
1. Berger, E. Zur allergischen pathogenese der cöliakie. Bibliotheca Paediatrica., 1958, 67, S.1, 55–56.
2. Catassi, C., Rätsch, I.M., Fabiani, E., Rossini, M. et al. Coeliac disease in the year 2000: exploring the iceberg. Lancet. 1994, 343, 8891, 200–203.
3. Ciccocioppo, R., Sabatino, D.I., Parroni, R., Dalo, D. et al. Cytolytic mechanisms of intraepithelial lymphocytes in coeliac disease (CoD). Clin Exp Immunol, 2000, 120, 2, 235–240.
4. Dietrich, W., Ehnis, T., Bauer, M. Donner, P. et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med, 1997, 3, 7, 797–801.
5. Frič, P., Zavoral, M. Celiakální sprue dospělých - opojímená choroba. Prakt Lék, 2003, 83, 2, 62–65.
6. Frič, P. Celiakální sprue – současný stav v ČR. Čes a Slov Gastroent a Hepatol, 2005, 59, S.1.
7. Füleová, A., Stanková, S., Halušková, V., Majorová, E. et al. Je črevná biopsia aj v súčasnosti nevyhnutná pre stanovenie diagnózy celiakia? Pediatria (Bratisl.). 2008, 3, 1, 43–47.
8. Guandalini, S., Gupta, P. Do you still need a biopsy to diagnose celiac disease? Curr Gastroenterol Rep, 2001, 3, 5, 385–391.
9. Hill, P.G., Holmes, G.K.T. Coeliac disease a biopsy is not always necessary for diagnosis. Aliment Pharm Ther, 2008, 27, 7, 572–577.
10. Hrdá, P., Šterzl, I. Vyšetření autoprotilátek – současné možnosti. Int Med Prax, 2003, 8, 5, 410–413.
11. Chorselski, T.P., Sulej, J., Tchorsewska, H., Jablonska, S. et al. IgA class endomysium antibodies in dermatitis herpetiformis and celiac disease, 325–334. In: Beutner E.H., Nissengard R.J., Albibi B (eds.): Defined-immunofluorescence and realted cytochemical methods. Ann. N.Y. Acad. Sci., 1983.
12. Janatková, I., Malíčková, K., Fučíková, T., Kožnarová, R. et al. Diagnostický přínos stanovení autoprotilátek u gluten-sensitivní enteropatie. Epidemiol Mikrobiol Imunol, 2002, 51, 3, 125–130.
13. Jankowiak, C., Ludwig, D. Frequent causes of diarrhea: Celiac disease and lactose intolerance. Med Klin (Munich). 2008, 103, 6, 413–422.
14. Kárpáti, S., Török, E., Kósnai, I. IgA class antibody against human jejunum in sera of children with dermatitis herpetiformis. J Invest Dermatol, 1986, 87, 6, 703–706.
15. Kollárová, H., Pektor, R., Šmajstrla, V., Dvořáčková, J. et al. Rutinní biopsie z duodena prováděna během gastroskopie - jedna z možností vyhledávaní asymptomatické celiakie. Čes a Slov Gastroent a Hepatol, 2007, 61, 5, 245–248.
16. Kotalová, R., Nevoral, J., Šmídová, J. Tkáňové protilátky v diagnostice celiakální sprue. Česk-Slov Pediat, 1996, 51, 11, 680–687.
17. Lísová, S., Ehrmann, J., Kolek, A., Sedláková, E. et al. Imunohistochemická studie mechanismů apoptózy a proliferace ve sliznici tenkého střeva u celiakální sprue. Česk-Slov Patol, 2005, 41, 3, 85–93.
18. Lukáš, Z. Histopatologie a diferenciální diagnostika celiakální sprue. Česk-Slov Patol, 2004, 40, 1, 3–6.
19. Makovický, P., Makovický, P., Jílek, F. Od historických názorov a poznatkov až po súčasné úlohy na poli celiakie. Epidemiol Mikrobiol Imunol, 2008, 57, 3, 90–96.
20. Makovický, P., Makovický, P., Maxová, M. Typical and atypical forms of celiac disease from a pathologist viewpoint. Čes a Slov Gastroent a Hepatol, 2008, 62, S.3.
21. Makovický, P., Makovický, P., Maxová, M. Možnosti diagnostiky celiakie v bioptickej praxi. Česk-Slov Patol, 2009, 45, 1, 14-18.
22. Malíčková, K., Janatková, I., Šandová, P., Fučíková, T. Imunologická laboratórní vyšetření při podezření na celiakii. Int Med Prax, 2005, 10, 7, 440–443.
23. Prokopová, L. Celiakie – co má vědět ambulantní internista. Int Med Prax, 2008, 9, 10, 233–239.
24. Rostami, K., Villanacci, V. Microscopic enteritis: novel prospect in coeliac disease clinical and immuno-histogenesis evolution in diagnosis and treatment strategies. Dig Liver Dis, 41, 2009, 4, 245–252.
25. Salazar, L.I.F., Ferrera, N.T., Jiménez, B.V., Colón, M.N. et al. Diagnostic problems in adult celiac disease. Rev Esp Enferm Dig, 2008, 1, 24–28.
26. Salmi, T.T., Collin, P., Korponay-Szabó, I.R., Laurila, K. et al. Endomysial antibody-negative coeliac disease: clinical characteristics and intestinal autoantibody deposits. Gut, 2006, 55, 12, 1746–1753.
27. Seah, P.P., Fry, L., Hofbrand, A.V. Tissue antibodies in dermatitis herpetiformis and adult coeliac disease. Lancet. 1971, 1, 7704, 834–836.
28. Setty, M., Hormaza, L., Guandalini, S. Celiac disease: risk assessment, diagnosis, and monitoring. Mol Diagn Ther, 2008, 12, 5, 289–298.
29. Tlaskalova-Hogenova, H., Šťepánková, R., Tučková, L., Farré, M. A. et al. Autoimmune reactions induced by gliadin. Adv Exp Med Biol, 1995, 371B, 1191–1198.
30. Vécsei, A.K., Graf, U.B., Vogelsang H. Follow-up of adult celiac patients: which nonivasive test reflects mucosal status most a reliably? Endoscopy. 2009, 41, 2, 123–128.
Labels
Hygiene and epidemiology Medical virology Clinical microbiologyArticle was published in
Epidemiology, Microbiology, Immunology
![Issue 4](https://www.prolekare.cz/media/cache/resolve/journal_issue/media/image_pdf/b3d0727a1765a136ffb08aa55fa91705.jpeg)
2009 Issue 4
Most read in this issue
- Antibiotic Resistance and Biofilm Formation in Pseudomonas aeruginosa Strains Isolated from Patients with Urinary Tract Infections
- Dynamics of the Incidence of Creutzfeldt-Jakob Disease in Slovakia in 1975-2008
- Serum Anti-Endomysium Antibodies (AEA) in the Diagnostic Algorithm of Coeliac Disease
- Contribution of HCV core antigen testing in HCV diagnosis by test from the company Abbott Laboratories