Ilya Ilich Metchnikov and Paul Ehrlich: 1908 Nobel Prize Winners for their Research on Immunity.
Authors:
Lokaj J.. 1; C. John 2
Authors‘ workplace:
Ústav klinické imunologie a alergologie LF MU, Brno
1; Ústav imunologie a mikrobiologie 1. LF UK, Praha
2
Published in:
Epidemiol. Mikrobiol. Imunol. 57, 2008, č. 4, s. 119-124
Overview
The Nobel Prize in Physiology or Medicine in 1908 was awarded to Ilya I. Mechnikov and Paul Ehrlich for recognition of their work on immunity. Mechnikov have discovered phagocytes and phagocytosis as the basis of natural cellular immunity. His „phagocytic theory“ is the principle of immunological concept „self and not self“ as the prerequisition of physiological inflammation, and selfmaintaining of organism. Ehrlich developed the methods for standardization of antibody activity in immune sera, described neutralizing and complement-depending effect of antibodies and enunciated the „side-chain“ theory of the formation of antibodies. Their concept of the key-stone of immunity was different, but they expressed the basic paradigma of immunology: immunity imply the protection of identity and guarantee the integrity of organism. Both are the founders of immunology as the scientific discipline. Discoveries and conceptions of I. Mechnikov and P. Ehrlich exceedingly influenced development of immunology and are also applicable, instructive and suggestive in contemporary immunology and microbiology.
Sources
1. Abbas, A. K., Lichtman, A., Pillai, S. Cellular and molecular immunology. 6th ed., Saunders Elsevier 2007, 566 s. ISBN 978-0-8089-2358-9.
2. Amos, B. (ed.) Progress in immunology. First international congress of immunology. Academic Press New York and London 1971, 1554 s. ISBN 0-12-057550-7.
3. Cruse, J. M., Lewis, R. E. Historical atlas of immunology. Taylor & Francis, London and New York 2005, 338 s. ISBN 1-84214-217-8
4. Hirsch, J. G., Hirsch, B. I. Metchnikoff’s life and scientific contributions in historical perspectives. In Karnovsky, M.L., Bolis, L. (ed.) Phagocytosis. Past and future. Academic Press 1982, 592 s., 1-12. ISBN 0-12-400050-9.
5. Holub, M., Jarošková, L. (ed.) Mechanisms of antibody formation. Proceedings of a symposium held in Prague, May 27-31, 1959. Nakladatelství ČSAV Praha 1960, 385s.
6. John, C. Ilja Iljič Mečnikov. Čas Lék čes 2007, 146, 4, 427.
7. John, C. Paul Ehrlich. Čas Lék čes 2007, 146, 5, 522-523.
8. Kabelík, J. Nauka o sérových protilátkách (serologie). Melantrich Praha 1939, 272 s.
9. Kuhn, T. S. Struktura vědeckých revolucí. Oikoymenh. Edice Oikúmené Praha 1997, 206 s. ISBN 80-86005-54-2.
10. Lechevalier, H. A., Solotorovsky M. Three Centuries of Microbiology. McGraw-Hill Book Company 1965, 533 s.
11. Lokaj, J. Mečnikovské inspirace. Čas Lék čes 2007, 146, 4, 428
12. Lokaj, J. Ehrlichův vtisk v imunologii. Čas Lék čes 2007, 146, 5, 523-524.
13. Mak, T. W., Saunders , M. E. The immune response. Basic and clinical principles. Elsevier 2006, 1194 s. ISBN-13: 978-0-12-088451-3
14. Mečnikov, I. Otázky imunity (český překlad L. Jiroutková, B. Johnová, C. John, I. Říha, M. Sedláčková, J. Sedláček, J. Součková). Nakladatelství ČSAV Praha 1955, 457 s.
15. Paul , W. E. Fundamental immunology, 5th ed. Lippincott Williams & Wilkins 2003, 1701 s. ISBN 0-7817-3514-9.
16. Tauber, A. I. The immune self: Theory or metaphor? (Cambridge studies in philosophy and Biology). Cambridge University Press 1994, 354 s. ISBN 0-521-46188-X.
Labels
Hygiene and epidemiology Medical virology Clinical microbiologyArticle was published in
Epidemiology, Microbiology, Immunology
2008 Issue 4
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- Ilya Ilich Metchnikov and Paul Ehrlich: 1908 Nobel Prize Winners for their Research on Immunity.