#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Antibodies AgainstLow Density Oxidized Lipoproteins in Type 2 Diabetics


Authors: K. Malíčková;  J. Škrha 1;  I. Janatková;  Z. Vaňková;  T. Fučíková
Authors‘ workplace: Ústav imunologie a mikrobiologie VFN a 1. LF UK Praha 1III. interní klinika VFN a 1. LF UK Praha
Published in: Epidemiol. Mikrobiol. Imunol. , 2004, č. 3, s. 131-135
Category:

Overview

Oxidative modification of low density lipoproteins ( LDL ) is an important factor in the developmentof macrovascular atherosclerotic complications in patiens with type 2 diabetes mellitus. Recentlyautoantibodies against oxidized LDL ( anti-oxLDL ) have been suggested as a potential marker ofLDL oxidation in vivo.The purpose of this study was to investigate the presence and levels of anti-oxLDL in patients withtype 2 diabetes compared to healthy persons.We determined the serum concentrations of anti-oxLDL in 20 type 2 diabetic patiens with differentdegree and type of atherosclerotic vascular damage. Two healthy population groups: 20 young blooddonors and 20 age and gender matched persons were used as controls. Anti-oxLDL positivity rateswere distinctively higher in both control groups. Concentrřations of anti-oxLDL were significantlylower in diabetic patients compared to both control groups. The incidence rates and levels ofanti-oxLDL in both control groups were similar. Anti-oxLDL levels in the diabetes group did notcorrelate with the degree of macrovascular damage, serum total cholesterol, LDL cholesterol andtriglyceride concentrations. We did not find any significant relationship between anti-oxLDL andother oxidative stress factors (superoxide dismutase, malondialdehyde, C and E vitamins ). Wesuppose that anti-oxLDL may have an antiatherogenic protective role in healthy people but are notapplicable to be an in vivo marker of LDL oxidation and macrovascular atherosclerotic vasculardamage.

Key words:
antibodies against oxidized low density lipoproteins – anti-oxLDL – atherosclerosis –diabetes mellitus.

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Hygiene and epidemiology Medical virology Clinical microbiology
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#