Avidity of Immunoglobulins G in Infectious Diseases

Overview

The paper reviews results reached so far about avidity of immunoglobulins G in viral, parasitic andbacterial infectious diseases.The general introductory part begins with explanation of immunologic basis in maturation ofavidity of immunoglobulins G and proceeds up to a survey of methods used for the determinationof avidity. It also deals with the modes of evaluation in these methods and comments on theiradvantages and disadvantages.The part devoted to individual infectious diseases brings the most important information aboutavidity of immunoglobulins G in specific infections, especially in view of their (even potential)practical medical application, mainly in determining the phase of infection in pregnant women andin patients after transplantation.The highest attention is paid to herpes virus infections, especially the cytomegalus virus and theinfections with Epstein-Barr virus, rubella and toxoplasmosis, therefore those infections, which inthe given situations clearly demonstrated the contribution of avidity analysis in the solution ofinterpretation-difficult conditions typical for serology, such as lasting levels of immunoglobulins Mand cross-reactivity of antibodies.

Key words:
avidity – immunoglobulins G – infectious diseases.