Metanefrický adenóm. Kazuistika a prehľad literatúry
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Radovan Kaštan 1; Monika Žižlavská 2
:
Department of Pathology, Hospital Jihlava, Czech Republic
1; Department of Urology, Hospital Jihlava, Czech Republic
2
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Čes.-slov. Patol., 55, 2019, No. 3, p. 165-169
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Original Articles
Metanefrický adenóm je vzácny renálny tumor s takmer výlučne benígnym správaním, ktorý môže klinicky i rádiologicky napodobňovať malignitu. Histologické vyšetrenie je preto v diagnostike rozhodujúce. Prezentujeme prípad 69 ročnej ženy s náhodným nálezom metanefrického adenómu ľavej obličky a súčasne svetlobunkového renálneho karcinómu druhostrannej obličky. V práci prezentujeme naše skúsenosti s týmto zriedkavým tumorom a prehľad literatúry so zameraním na diferenciálnu diagnózu. Histologická diferenciálna diagnóza metanefrického adenómu zahŕňa papilárny renálny karcinóm u dospelých pacientov a nefroblastóm (Wilmsov tumor), hlavne u detí. Imunohistochemické vyšetrenie a cytogenetická analýza môžu byť užitočné v diferenciálnej diagnostike týchto tumorov.
Klíčová slova:
imunohistochémia – metanefrický adenóm – diferenciálna diagnóza – renálny tumor
Sources
1. Pages A, Granier M. Nephrogenic nephroma. Arch Anat Cytol Pathol 1980; 28(2): 99-103.
2. Amin MB, Tamboli P, Javidan J, et al. Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 cases. Am J Surg Pathol 2002; 26(3): 281-291.
3. Davis CJ Jr, Barton JH, Sesterhenn IA, Mostofi FK. Metanephric adenoma. Clinicopathological study of fifty patients. Am J Surg Pathol 1995; 19(10): 1101-1114.
4. Hes O, Michal M, Perez-Montiel DM, et al. Metanefrický adenom. Popis 11 případů s průkazem kolagenních sferul v jednom nádoru. Cesk Patol 2002; 38: 101-106.
5. Bastide C, Rambeaud JJ, Bach AM, Russo P. Metanephric adenoma of the kidney: clinical and radiological study of nine cases. BJU Int 2009; 103(11): 1544-1548.6. Kinney SN, Eble JN, Hes O, et al. Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma. Mod Pathol 2015; 28(9): 1236-1248.
7. Mantoan Padilha M, Billis A, Allende D, Zhou M, Magi-Galluzzi C. Metanephric adenoma and solid variant of papillary renal cell carcinoma: common and distinctive features. Histopathology 2013; 62(6): 941-953.
8. Renshaw AA, Freyer DR, Hammers YA. Metastatic metanephric adenoma in a child. Am J Surg Pathol 2000; 24(4): 570-574.
9. Paner GP, Turk TM, Clark Ji, Lindgren V, Picken MM. Passive seeding in metanephric adenoma: a review of pseudometastatic lesions in perinephric lymph nodes. Arch Pathol Lab Med 2005; 129(10): 1317-1321.
10. Kohashi K, Oda Y, Nakamori M, et al. Multifocal metanephric adenoma in childhood. Pathol Int 2009; 59(1): 49-52.
11. Pasricha S, Gandhi JS, Gupta G, Mehta A, Beg S. Bilateral, multicentric metanephric adenoma associated with Wilms‘ tumor in child: a rare presentation with important diagnostic and therapeutic implications. Int J Urol 2012; 19(12): 1114-1117.
12. Gang L, Yuhong T, Renya Z, Hualin S, Shumin Z, Yuanjie N. Adult metanephric adenoma presumed to be all benign? A clinical perspective. BMC Cancer 2015; 15: 310.
13. Anastasiadis AG, Ebert T, Gerharz CD, Ackermann R. Simultaneous diagnosis of a metanephric adenoma and a clear cell carcinoma of the contralateral kidney. Eur Urol 2001; 39(2): 236-239.
14. Tsuji M, Murakami Y, Kanayama H, Sano T, Kagawa S. A case of renal metanephric adenoma: histologic, immunohistochemical and cytogenetic analyses. Int J Urol 1999; 6(4): 203-207.
15. Obulareddy SJ, Xin J, Truskinovsky AM, Anderson JK, Franklin MJ, Fudek AZ. Metanephric adenoma of the kidney: an unusual diagnostic challenge. Rare Tumors 2010; 30: 2(2): e38: 103-105.
16. Olgac S, Hutchinson B, Tickoo SK, Reuter VE. Alpha-methylacyl-CoA racemase as a marker in the differential diagnosis of metanephric adenoma. Mod Pathol 2006; 19(2): 218-224.
17. Chen L, Deng FM, Melamed J, Zhou M. Differential diagnosis of renal tumors with tubulopapillary architecture in children and young adults: a case report and review of literature. Am J Clin Exp Urol 2014; 2(3): 266-272.
18. Sun Z, Kan S, Zhang L, et al. Immunohistochemical phenotype and molecular pathological characteristics of metanephric adenoma. Int J Clin Exp Pathol 2015; 8(6): 6031-6036.
19. Kuroda N, Tanaka A, Ohe C, Nagashima Y. Recent advances of immunohistochemistry for diagnosis of renal tumors. Pathol Int 2013; 63(8): 381-390.
20. Yakirevich Y, Magi-Galluzzi C, Grada Z, Lu S, Resnick MB, Mangray S. Cadherin 17 is a sensitive and specific marker for metanephric adenoma. Am J Surg Pathol 2015; 39(4): 479-486.
21. Choueiri TK, Cheville J, Palescandolo E, et al. BRAF mutations in metanephric adenoma of the kidney. Eur Urol 2012; 62(5):917-922.
22. Udager AM, Pan J, Magers MJ, et al. Molecular and immunohistochemical characterization reveals novel BRAF mutations in metanephric adenoma. Am J Surg Pathol 2015; 39(4): 549-557.
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Czecho-Slovak Pathology
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