Hamartoma of mature cardiac myocytes.
Autopsy case report
Authors:
Šárka Hadravská 1,2; Magdaléna Dubová 1,2; Markéta Miesbauerová 1,2; Petr Mukenšnabl 1; Ondřej Daum 1,2; Alois Mádle 3; Karel Smetana 4
Authors‘ workplace:
Šiklův ústav patologie FN Plzeň, Univerzita Karlova v Praze, Lékařská fakulta v Plzni
1; Bioptická laboratoř, s. r. o., Plzeň
2; II. interní klinika FN Plzeň, Univerzita Karlova v Praze, Lékařská fakulta v Plzni
3; Interní oddělení FN Plzeň, Univerzita Karlova v Praze, Lékařská fakulta v Plzni
4
Published in:
Čes.-slov. Patol., 53, 2017, No. 4, p. 185-187
Category:
Original Article
Overview
Hamartoma of mature cardiac myocytes (HMCM) is a rare benign pseudoneoplastic myocardial lesion. We describe a case of 39-year-old Bulgarian woman living in the Czech Republic, who died because of rupture of anterior communicating artery aneurysm, and severe bronchopneumonia. An incidental finding at the autopsy was a whitish unencapsulated and not sharply demarcated tumor of the left ventricle and adjacent area of interventricular septum, which protruded above the plane of section. Microscopically the tumor consisted of various different forms of disorganized hypertrophic mature cardiac myocytes without vacuolization of cytoplasm, focally in a „herringbone“ pattern. Dilated venules and thickened intramural coronary arteries, and intervening bands of connective tissue were present between cardiomyocytes in the tumor. Immunohistochemical staining of MIB1 for the detection of proliferative activity was completely negative. No inflammatory infiltration, adipose tissue or calcifications were present in the tumor.
Keywords:
heart – hamartoma – mature cardiac myocytes
Sources
1. Fealey ME, Edwards WD, Miller DV, Menon SC, Dearani JA. Hamartomas of mature cardiac myocytes: report of 7 new cases and review of literature. Hum Pathol 2008; 39(7): 1064-1071.
2. Miller DV, Tazelaar HD. Cardiovascular pseudoneoplasms. Arch Pathol Lab Med 2010; 134(3): 362-368.
3. Zhang F, Yin N, Yin B, Xu S, Yang Y. Giant right atrial cystic hamartoma: a case report and literature review. BMJ Case Rep 2009. pii: bcr02.2009.1587.
4. Galeone A, Validire P, Gayet JB, Laborde F. Hamartoma of mature cardiac myocytes of the pulmonary infundibulum. Interact Cardiovasc Thorac Surg 2009; 9(6): 1029-1031.
5. Raffa GM, Malvindi PG, Settepani F, et al. Hamartoma of mature cardiac myocytes in adults and young: case report and literature review. Int J Cardiol 2013; 163(2): e28-30.
6. Menon SC, Miller DV, Cabalka AK, Hagler DJ. Hamartomas of mature cardiac myocytes. Eur J Echocardiogr 2008; 9(6): 835-839.
7. Tanimura A, Kato M, Morimatsu M. Cardiac hamartoma. A case report. Acta Pathol Jpn 1988; 38(11): 1481-1484.
8. Burke AP, Ribe JK, Bajaj AK, Edwards WD, Farb A, Virmani R. Hamartoma of mature cardiac myocytes. Hum Pathol 1998; 29(9): 904-909.
9. Movahedi N, Boroumand MA, Sotoudeh Anvari M, Yazdanifard P. Mature cardiac myocyte hamartoma in the right atrium. Asian Cardiovasc Thorac Ann 2008; 16(5): e47-48.
10. Gilman G, Wright RS, Glockner JF, et al. Ventricular septal hamartoma mimicking hypertrophic cardiomyopathy in a 41-year-old woman presenting with paroxysmal supraventricular tachycardia. J Am Soc Echocardiogr 2005; 18(3): 272-274.
11. Sturtz CL, Abt AB, Leuenberger UA, Damiano R. Hamartoma of mature cardiac myocytes: a case report. Mod Pathol 1998; 11(5): 496-499.
12. Dinh MH, Galvin JM, Aretz TH, Torchiana DF. Left ventricular hamartoma associated with ventricular tachycardia. Ann Thorac Surg 2001; 71(5): 1673-1675.
13. Fenoglio JJ, Jr., M. CAllister HA J, Ferrans VJ. Cardiac rhabdomyoma: a clinicopathologic and electron microscopic study. Am J Cardiol 1976; 38(2): 241-251.
14. Burke AP, Virmani R. Cardiac rhabdomyoma: a clinicopathologic study. Mod Pathol 1991; 4(1): 70-74.
15. de Silva DC, Johnston AW, Dean JC. Tuberous sclerosis--an unusual cause of seizures in an 18 year old. Scott Med J 1994; 39(1): 19-20.
16. Feldman PS, Meyer MW. Fibroelastic hamartoma (fibroma) of the heart. Cancer 1976; 38(1): 314-323.
17. Burke AP, Rosado-de-Christenson M, Templeton PA, Virmani R. Cardiac fibroma: clinicopathologic correlates and surgical treatment. J Thorac Cardiovasc Surg 1994; 108(5): 862-870.
18. Shehata BM, Patterson K, Thomas JE, Scala-Barnett D, Dasu S, Robinson HB. Histiocytoid cardiomyopathy: three new cases and a review of the literature. Pediatr Dev Pathol 1998; 1(1): 56-69.
Labels
Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2017 Issue 4
Most read in this issue
- What´s new in Ewing-like sarcoma family? Soft tissue and bone sarcomas with CIC/BCOR rearrangement. Review of the literature and first personal experience
- Molecular pathology of lung cancer in routine diagnostic practice: 2017 update
- Molecular mechanisms of primary and secondary resistance, molecular-genetic features and characteristics of KIT/PDGFRA non-mutated GISTs
-
Hamartoma of mature cardiac myocytes.
Autopsy case report