Pseudoglandulárny (adenoidný, akantolytický) dlaždicovobunkový karcinóm penisu. Popis prípadu

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: M. Zámečník ¹; P. Mukenšnabl ²; A. Chlumská ^2,3
: Medicyt, s. r. o., laboratory Trenčín, Slovak Republic ¹; Šikl's Department of Pathology, Faculty Hospital, Charles University, Plzeň, Czech Republic ²; Laboratory of Surgical Pathology, Plzeň, Czech Republic ³
: Čes.-slov. Patol., 47, 2011, No. 1, p. 15-18
: Original Article

Prezentovaný je prípad pseudoglandulárneho (adenoidného, akantolytického) dlaždicovobunkového karcinómu penisu u 60-ročného pacienta. Tumor obsahoval okrem štruktúr konvenčného dlaždicovobunkového karcinómu komponent pseudoglandulárny, ktorý napodobňoval tubuly adenokarcinómu. V epidermis vedľa tumoru nebola nájdená prekurzorová dysplastická lézia. Imunohistochemicky exprimovali bunky nádoru pancytokeratín AE1/AE3, p53 a p63, a boli negatívne na endotelové markery, CEA a p16. Farbenia na mucín boli negatívne. Metastázy boli prítomné v regionálnych lymfatických uzlinách a vo funiculus spermaticus. Štyri týždne po operácii sa objavili početné kožné/podkožné metastázy v podbrušku, v oboch ingvinách a na prednej mediálnej strane stehien. Vyšetrenie CT zistilo pakety metastaticky postihnutých lymfatických uzlín v panve. Vysoké štádium pri prezentácii tumoru a ďalší priebeh potvrdzujú, že pseudoglandulárny dlaždicovobunkový karcinóm penisu je vysoko agresívny tumor.

Key words:
adenosquamous carcinoma - pseudoglandular (adenoid, acantholytic) squamous cell carcinoma - penis - p16 - p53

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Article was published in

Czecho-Slovak Pathology

2011 Issue 1