Primary Synovial Sarcoma of the Kidney
Authors:
J. Drozenová 1; C. Povýšil 1; D. Tvrdík 1; M. Babjuk 2; T. Hanuš 2
Authors‘ workplace:
Ústav patologie 1. LF UK a VFN, Praha
1; Urologická klinika 1. LF UK a VFN, Praha
2
Published in:
Čes.-slov. Patol., 44, 2008, No. 1, p. 20-22
Category:
Original Article
Overview
The authors present two cases of primary synovial sarcoma of the kidney. Both patients had a tumor mass in the kidney with vascular invasion of the inferior vena cava and right atrium of the heart in case no. 1. In case no. 2 retroperitoneal lymph node metastasis and multiple metastases to both lungs were observed. Radical nephrectomies were performed in both patients. Histologically, the tumor in case no. 1 was monophasic and in case no. 2 poorly differentiated. Immunohistochemically, vimentin was diffusely positive and a few tumor cells were positive for epithelial membrane antigen. The tumor cells were negative for keratins, S- 100 protein, CD 34, smooth muscle actin, and desmin. In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX 1 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma.
Key words:
synovial sarcoma – kidney – SYT-SSX – RT-PCR
Sources
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Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2008 Issue 1
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