#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Malakoplakia in a Renal Transplant: a Case Report


Authors: K. Hušek;  D. Sobotová
Authors‘ workplace: I. patologickoanatomický ústav MU, Brno
Published in: Čes.-slov. Patol., , 2000, No. 2, p. 65-70
Category:

Overview

Malakoplakia is an uncommon inflammatory condition rarely involving parenchyma of transplan-ted kidney. We report a 44-year-old female recipient of a cadaveric renal allograft treated withcyclosporin A and prednison. After transplantation, E. coli and Citrobacter bacteruria occuredand three years later decreased graft function developed. Percutaneous needle biopsy was perfor-med and diagnosis of malakoplakia was established. Histologically, interstitial sheets of plasmo-cytes and histiocytes with periodic acid-Shiff positive cytoplasm containing Michaelis-Gutmannbodies were present. Ultrastructurally, phagolysosomes containing membrane fragments and va-rious developmental stages of inclusions to fully developed Michaelis-Gutmann bodies werefound. The patient was treated with co-piperacillin and subsequently pefloxacin and renal functi-ons improved after six months follow-up. Our case suggests that malakoplakia represents anabnormal defective histiocytic response to the infection in the setting of immunosuppressivetherapy.

Key words:
malakoplakia-kidney transplantation - diagnosis, kidney disease - pathology - needle

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Anatomical pathology Forensic medical examiner Toxicology
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#