#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Severe iron intoxication in a 16-year-old patient


Authors: Kadlečíková Martina 1;  Ondrušová Adriana 1,2;  Poláková Katarína 1;  Slaný Jaroslav 1,3
Authors‘ workplace: Pediatrická klinika, Fakultná nemocnica Trnava 1;  Fakulta zdravotníctva, Trenčianska univerzita, Alexandra Dubčeka v Trenčíne 2;  Fakulta zdravotníctva, a sociálnej práce, Trnavská univerzita 3
Published in: Čes-slov Pediat 2023; 78 (1): 30-33.
Category:
doi: https://doi.org/10.55095/CSPediatrie2023/005

Overview

Intoxications in children still represent a serious problem in the Slovak Republic and account for 50 % of all intoxications consulted with the National Toxicological Information Center (NTIC) in Bratislava. Acute iron intoxication is a serious condition that can progress rapidly to multiorgan failure and death. In this article, we present a case of intoxication of a 16-year-old patient who intentionally ingested 50 tablets of an iron-containing preparation. The total dose corresponded to 5000 mg of elemental iron, which at a patient weight of 50 kg was 100 mg/kg. Due to signs of severe intoxication and high ingested iron dose, we indicated the administration of an antidote to adjust the clinical condition and serum iron levels. Patient recovered without sequelae due to the prompt initiation of detoxification treatment. Given that iron poisoning can lead to serious complications, we use this case report to point out the importance of knowing the clinical picture, course and early initiation of treatment in a patient with acute intoxication.

Keywords:

poisoning in children – iron intoxication – toxic noxa – deferoxamine – suicidium


Sources

1. Jepse F, Ryan M. Poisoning in children. Current Paediatrics 2005; 15: 563– 568.

2. Yesiler FI, et al. Acute iron poisoning: a case report. MOJ Clin Med Case Rep 2018; 8 (1): 16–17. http://medcraveonline.com/MOJCR/MOJCR- 08-00230.pdf.

3. Yuen H-W, et al. Iron Toxicity. StatPearls 2021. Dostupné na: https://www. ncbi.nlm.nih.gov/books/NBK459224/

4. Simonse E, et al. Iron autointoxication in a 16-year-old girl: a protective role for hepcidin? Ann Clin Biochem Int J Lab Med 2013; 50 (1): 76–79.

5. Sane M, et al. Fatal iron toxicity in an adult: Clinical profile and review. Indian J Crit Care Med 2018; 22 (11): 801–803.

6. Sorbifer Durules. Súhrn charakteristických vlastností lieku. Dostupné na: https://www.sukl.sk/hlavna-stranka/slovenska-verzia/pomocne-stranky/ detail-lieku?page_id=386&lie_id=97402.

7. Šagát T, et al. Pediatria. 3. vyd. Bratislava: Herba 2019: 1525–1526.

8. Cagáňová B. Predávkovanie železom v gravidite. Lekárnik 2007; 12 (8).

9. Anthony S, et al. Iron ingestion: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol 2005; 43 (6): 553–570.

10. Liebelt EL. Acute iron poisoning. Dostupné na: https://www.uptodate. com/contents/acute-iron-poisoning?search=iron%20intoxication&source= search_result&selectedTitle=1~59&usage_type=default&display_rank= 1#H20

11. Fernández, S, et al. Acute iron intoxication: change in urine color during chelation therapy with deferoxamine. Intensive Care Med 2014; 40(104).

12. Ioannides, A, Panisello, J. Acute respiratory distress syndrome in children with acute iron poisoning: the role of intravenous desferrioxamine. Eur J Pediatr 2000; 159: 158–159.

13. Clinical Practice Guidelines. Iron poisoning. Dostupné na: https://www. rch.org.au/clinicalguide/guideline_index/Iron_poisoning/

14. Proudfoot AT , et al. Management of acute iron poisoning. Med Toxicol 1986; 1(2): 83–100.

15. Sankar J, et al. Near fatal iron intoxication managed conservatively. BMJ Case Rep 2013.

16. Plačková S. Otravy u detí. Pediatr prax 2014; 15(5): 193–195.

17. Národné centrum zdravotníckych informácií. Samovraždy a samovražedné pokusy v Slovenskej republike. Dostupné na: https://data.nczisk.sk/statisticke_ vystupy/Samovrazdy_samovrazedne_pokusy/Samovrazdy_a_samovrazedne_ pokusy_v_SR_2021.pdf

Labels
Neonatology Paediatrics General practitioner for children and adolescents
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#