#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Molecularly Defined Allergens and Their Use in the Diagnostics of Allergic Inflammation (Atopic Dermatitis)


Authors: R. Vaňková 1;  J. Čelakovská 2;  J. Krejsek 1;  I. Krčmová 1;  C. Andrýs 1
Authors‘ workplace: Ústav klinické imunologie a alergologie, Univerzita Karlova, Lékařská fakulta v Hradci Králové, Fakultní nemocnice Hradec Králové, přednosta prof. RNDr. Jan Krejsek, CSc. 1;  Klinika nemocí kožních a pohlavních, Univerzita Karlova, Lékařská fakulta v Hradci Králové, Fakultní nemocnice, Hradec Králové, přednosta doc. MUDr. Miloslav Salavec, CSc. 2
Published in: Čes-slov Derm, 95, 2020, No. 4, p. 127-140
Category: Reviews

Overview

The determination of specific IgE antibodies is an integral part of the diagnostics of allergic diseases. Extracts from natural allergenic sources that contain a whole complex of both allergenic and non-allergenic components are commonly used. The use of molecularly defined allergens is a next step in making the diagnosis more accurate, identifying causative allergens for allergen immunotherapy, and predicting severe reactions. Even the response to species-specific allergens or cross-reactive allergens can be distinguished with certain reservations. The importance of specific IgE antibody analysis can be demonstrated on the most important food allergens, such as soy, cow milk, eggs, nuts, fish, crustaceans, molluscs and wheat. The level of specific IgE antibodies can be determined against individual molecular allergens or a multiplex technique can be used to obtain a comprehensive picture of the patient's sensitization. Whereas these methods are used in the diagnostics of respiratory forms of allergic inflammation, anaphylaxis and food allergies, multiplex assays are not commonly used in the diagnostics of atopic dermatitis yet. The aim of the article is to inform about possibilities of laboratory diagnostics of molecular allergens in patients suffering from atopic dermatitis.

Keywords:

atopic dermatitis – component-resolved diagnosis – food allergy – ISAC test – ALEX test


Sources

  1. AALBERSE, R. C. Structural biology of allergens. Journal of Allergy and Clinical Immunology, 2000, 106(2), p. 228–238.

  2. ASERO, R., PRAVETTONI, V. Anaphylaxis to plant-foods and pollen allergens in patients with lipid transfer protein syndrome. Current Opinion in Allergy and Clinical Immunology, 2013, 13(4), p. 379–385.

  3. BALLMER-WEBER, B. K., LIDHOLM, J., LANGE, L. et al. Allergen Recognition Patterns in Walnut Allergy Are Age Dependent and Correlate with the Severity of Allergic Reactions. The Journal of Allergy and Clinical Immunology: In Practice, 2019, 7(5), p. 1560–1567.

  4. BENHAMOU, A. H., ZAMORA, S. A., EIGENMANN, P. A. Correlation between specific immunoglobulin E levels and the severity of reactions in egg allergic patients. Pediatric Allergy and Immunology, 2008, 19, p. 173–179.

  5. BOJCUKOVA, J., VLAS, T., FORSTENLECHNER, P., PANZNER, P. Comparison of two multiplex arrays in the diagnostics of allergy. Clinical and Translational Allergy, 2019, 9(31), p. 1–6.

   6.        ČELAKOVSKÁ, J., BUKAČ, J., VAŇKOVÁ, R., KRČMOVÁ, I., KREJSEK, J., ANDRÝS, C. Sensitisation to molecular allergens of Alternaria alternata, Cladosporium herbarum, Aspergillus fumigatus in atopic dermatitis patients. Food and Agricultural Immunology, 2019, 30(1), p. 1097–1111.

   7.        CELAKOVSKA, J., BUKAC, J., ETTLER, K., VANECKOVA, J., ETTLEROVA, K., KREJSEK, J. Sensitisation to outdoor and indoor fungi in atopic dermatitis patients and the relation to the occurrence of food allergy to peanuts and walnuts. Mycoses, 2018, 61(9), p. 698–703.

   8.        CELAKOVSKA, J., BUKAC, J., ETTLER, K., VANECKOVA, J., KRCMOVA, I., ETTLEROVA, K. Sensitisation to fungi in atopic dermatitis patients over 14 years of age and the relation to the occurrence of food hypersensitivity reactions. Mycoses, 2018, 61(2), p. 88–95.

   9.        CIANFERONI, A. Wheat Allergy: diagnosis and management. Journal of Asthma and Allergy, 2016, 29(9), p. 13–25.

10. COSTA, J., CARRAPATOSO, I., OLIVEIRA, M. B. P. P., MAFRA, I. Walnut allergens: molecular characterization, detection and clinical relevance. Clinical and Experimental Allergy, 2014, 44(3), p. 319–341.

11. DATEMA, M. R., VAN REE, R., ASERO, R. et al. Component-resolved diagnosis and beyond: Multivariable regression models to predict severity of hazelnut allergy. Allergy, 2018, 73(3), p. 549–559.

12. DODIG, S., ČEPELAK, I. The potential of component-resolved diagnosis in laboratory diagnostics of allergy. Biochemia Medica, 2018, 28(2), p. 1–9.

13. FDA Approves Aimmune’s PALFORZIA™ as First Treatment for Peanut Allergy. Aimmune therapeutics [online]. Aimmune Therapeutics, ©2019 [cit. 2020-03-02]. Dostupné na www: http://ir.aimmune.com/news-releases/news-release-details/fda-approves-aimmunes-palforziatm-first-treatment-peanut-allergy.

14. FERNÁNDEZ-RIVAS, M. Fruit and Vegetable Allergy. Chemical Immunology and Allergy, 2015, 101, p. 162–170.

15. FIOCCHI, A., BOUYGUE, G. R., ALBARINI, M., RESTANI, P. Molecular diagnosis of cow᾿s milk allergy. Current Opinion in Allergy and Clinical Immunology, 2011, 11(3), p. 216–221.

16. FLORES, K. J., MCCLEARY, N., NWARU, B., STODDART, A., SHEIKH, A. Diagnostic accuracy, risk assessment, and cost-effectiveness of component-resolved diagnostics for food allergy: A systematic review. Allergy, 2018, 73(8), p. 1609–1621.

17. FUCHS, M. Potravinová alergie a intolerance. Praha: Mladá fronta, 2016. Edice postgraduální medicíny. ISBN 978-80-204-3757-0.

18. GEISELHART, S., HOFFMANN-SOMMERGRUBER, K., BUBLIN, M. Tree nut allergens. Molecular Immunology, 2018, 100, p. 71–81.

19. HAGE, M., HAMSTEN, C., VALENTA, R. ImmunoCAP assays: Pros and cons in allergology. Journal of Allergy and Clinical Immunology, 2017, 140(4), p. 974–977.

20. HEFFLER, E., PUGGIONI, F., PEVERI, S., MONTAGNI, M., CANONICA, G. W., MELIOLI, G. Extended IgE profile based on an allergen macroarray: a novel tool for precision medicine in allergy diagnosis. World Allergy Organization Journal, 2018, 11(1), p. 1–7.

21. HEMMER, W., ALTMANN, F., HOLZWEBER, F., GRUBER, C., WANTKE, F., WÖHRL, S. ImmunoCAP cellulose displays cross-reactive carbohydrate determinant (CCD) epitopes and can cause false-positive test results in patients with high anti-CCD IgE antibody levels. Journal of Allergy and Clinical Immunology, 2018, 141(1), p. 372–381.

22. HOCHWALLNER, H., SCHULMEISTER, U., SWOBODA, I., SPITZAUER S., VALEMTA, R. Cow´s milk allergy: From allergens to new forms of diagnosis, therapy and prevention. Methods, 2014, 66(1), p. 22–33.

23. HOLZHAUSER, T., WACKERMANN, O., BALLMER-WEBER, B.K., BINDSLEV-JENSEN, C., SCIBILIA, J., PERONO-GAROFFO, L., UTSUMI, S., POULSEN, L. K., VIETHS, S. Soybean (Glycine max) allergy in Europe: Gly m 5 (b-conglycinin) and Gly m 6 (glycinin) are potential diagnostic markers for severe allergic reactions to soy. Journal of Allergy and Clinical Immunology, 2009, 123(2), p. 452–458.

24. CHOI, J., ROH, J., LEE, J. Clinical Availability of Component-Resolved Diagnosis Using Microarray Technology in Atopic Dermatitis. Annals of Dermatology, 2014, 26(4), p. 437–446.

25. ITO, K., SJÖLANDER, S., SATO, S., MOVERARE, R., TANAKA, A., SÖDERSTRÖM, L., BORRES, M., POORAFSHAR, M., EBISAWA, M. IgE to Gly m 5 and Gly m 6 is associated with severe allergic reactions to soybean in Japanese children. Journal of Allergy and Clinical Immunology, 2011, 128(3), p. 673–675.

26. JAKOB, T., FORSTENLECHNER, P., MATRICARDI, P., KLEINE-TEBBE, J. Molecular allergy diagnostics using multiplex assays: methodological and practical considerations for use in research and clinical routine. Allergo Journal International, 2015, 24, p. 320–332.

27. JOHANSSON, S, HOURIHANE, J., BOUSQUET, J. et al. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy: European Journal of Allergy and Clinical Immunology, 2001, 56, p. 13–24.

28. KLEMANS, R. J. B., DIANNE, O., KNOL, M. et al. The diagnostic value of specific IgE to Ara h 2 to predict peanut allergy in children is comparable to a validated and updated diagnostic prediction model. Journal of Allergy and Clinical Immunology, 2013, 131, p.157–163.

29. KLEMANS, R. J., KNOL, E. F, MICHELSEN--HUISMAN, A., PASMANS, S. G., KRUIJF-BROEK-MAN, W., BRUIJNZEEL-KOOMEN, C. A., HOFFEN, E., KNULST, A. C. Components in soy allergy diagnostics: Gly m 2S albumin has the best diagnostic value in adults. Allergy, 2013, 68(11), p. 1396–1402.

30. KREJSEK, J., ANDRÝS, C., KRČMOVÁ, I. Imunologie člověka. Hradec Králové: Garamon, 2016, s. 213–222. ISBN 978-80-86472-74-4.

31. KUEHN, A., SWOBODA, I., ARUMUGAM, K., HILGER, C., HENTGES, F. Fish allergens at a glance: variable allergenicity of parvalbumins, the major fish allergens. Frontiers in Immunology, 2014, 5(179), p. 1–8.

32. LEUNG, D., BIEBER, T. Atopic dermatitis. Lancet, 2003, 361, p. 151–160.

33. LOPATA, A. L., ANDREAS, L., KAMATH, S. Shellfish allergy diagnosis – gaps and needs. Current Allergy and Clinical Immunology, 2012, 25(2), p. 60–66.

34. LOPATA, A. L., KLEINE-TEBBE, J., KAMATH, S. D. Allergens and molecular diagnostics of shellfish allergy: Part 22 of the Series Molecular Allergology. Allegro Journal International, 2016, 25(7), p. 210–218.

35. MARI, A., WALLNER, M., FERREIRA, F. Fagales pollen sensitization in a birch-free area: a respiratory cohort survey using Fagales pollen extracts and birch recombinant allergens (rBet v 1, rBet v 2, rBet v 4). Clinical and Experimental Allergy, 2003, 33(10), p. 1419–1428.

36.       MARTÍNEZ-ARANGUREN, R., LIZASO, M., GOIKOETXEA, M., GARCÍA, B., CABRERA-FREI­-TAG, P., TRELLEZ, O., SANZ, M. Is the determination of specific IgE against components using ISAC 112 a reproducible technique? PLOS One, 2014, 9(2), p. 1–7.

37. MARTORELL, A., ALONSO, E., BONÉ, J., ECHEVERRÍA, L., LÓPEZ, M. C., MARTÍN, F., NEVOT, S., PLAZA, A. M. Position document: IgE-mediated allergy to egg protein. Allergologia et Immunopathologia, 2013, 41(5), p. 320–336.

38. MASTHOFF, L. J., MATTSSON, L., ZUIDMEER-JONGEJAN, L. et al. Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults. Journal of Allergy and Clinical Immunology, 2013, 132(2), p. 393–399.

39. MATRICARDI, P. M., KLEINE-TEBBE, J., HOFFMANN, H. J. et al. EAACI Molecular Allergology User‘s Guide. Pediatric Allergy and Immunology, 2016, 27, p. 213–223.

40. MATRICARDI, P. M., KLEINE-TEBBE, J., HOFFMANN, H. J. et al. EAACI Molecular Allergology User‘s Guide. Pediatric Allergy and Immunology, 2016, 27, p. 337–344.

41. MELIOLI, G., BONIFAZI, F., BONINI, S., MAGGI, E., MUSSAP, M., PASSALACQUA, G., ROSSI, E., VACCA, A., CANONICA, G. The ImmunoCAP ISAC molecular allergology approach in adult multi-sensitized Italian patients with respiratory symptoms. Clinical Biochemistry, 2011, 44, p. 1005–1011.

42. MOTHES-LUKSCH, N., JORDAKIEVA, G., HINTERHÖLZL, L., JENSEN, A. N., HALLMANN, P. K, KUNDI, M., JENSEN-JAROLIM, E. Allergy diagnosis from symptoms to molecules, or from molecules to symptoms: a comparative clinical study. World Allergy Organization Journal, 2018, 11(1), p. 1–11.

43. OTT, H., BARON, J. M., HEISE, R., OCKLENBURG, C. et al. Clinical usefulness of microarray-based IgE detection in children with suspected food allergy. Allergy, 2008, 63(11), p. 1521–1528.

44. PAHR, S., CONSTANTIN, C., MARI, A., SCHEIBLHOFER, S., THALHAMER, J., EBNER, C., VRTALA, S., MITTERMANN, I., VALENTA, R. Molecular characterization of wheat allergens specifically recognized by patients suffering from wheat-induced respiratory allergy. Clinical and Experimental Allergy, 2012, 42(4), p. 597–609.

45. PALLADINO, C., BREITENEDER, H. Peanut allergens. Molecular Immunology, 2018, 100, p. 58–70.

46. POMÉS, A., DAVIES, J. M., GADERMAIER, G. et al. WHO/IUIS Allergen Nomenclature: Providing a common language. Molecular Immunology, 2018, 100, p. 3–13.

47. PROCHÁZKOVÁ, V., SÁNCHEZ, D., ŠTĚPÁNOVÁ HONZOVÁ, S., HOSPODKOVÁ, M., HOFFMANOVÁ, I. Neglutenové proteiny pšeničného zrna v imunopatogenezi onemocnění zažívacího traktu. Alergie, 2018, 20(3), p. 156–161.

48. QUIRCE, S., MARYNIN, F., UMPIERREZ, A. et al. Chicken serum albumin (Gal d 5*) is a partially heat-labile inhalant and food allergen implicated in the bird-egg syndrome. Allergy, 2001,56, p. 754–762.

49. RADAUER, C., NANDY, A., FERREIRA, F., GOODMAN, R. E., LARSEN, J. N., LIDHOLM, J., POMES, A., RAULF-HEIMSOTH, M., ROZYNEK, P., THOMAS, W. R., BREITENEDER, H. Update of the WHO/IUIS allergen nomenclature database based on analysis of allergen sequences. Allergy, 2014, 69, p. 413–419.

50. RAJAMOHAMED, S. H., BOYE, J. I. Processing foods without peanuts and tree nuts. Allergen Mana­gement in the Food Industry, 2010, 11, p. 289–331.

51. RÖCKMANN, H., GEEL, M. J., KNULST, A. C., HUISKES, J., BRUIJNZEEL-KOOMEN, C., BRUIN-WELLER, M. S. Food allergen sensitization pattern in adults in relation to severity of atopic dermatitis. Clinical and Translational Allergy, 2014, 4(1), p. 1–9.

52. SAMASCA, G., SUR, G., IANCU, M., LUPAN, I., DELEANU, D. Current trends and investigative developments in wheat allergy. International Reviews of Immunology, 2015, 34, 538–541.

53.       TONG, W. S., YUEN, A. W. T., WAI, CH. Y. Y., LEUNG, N. Y. H., CHU, K. H., LEUNG, P. S. C. Diagnosis of fish and shellfish allergies. Journal of Asthma and Allergy, 2018, 11, p. 247–260.

54. TREUDLER, R., SIMON, J. C. Overview of Component Resolved Diagnostics. Current Allergy and Asthma Reports, 2013, 13, p. 110–117.

55. VALENTA, R., TWAROCH, T., SWOBODA, I. Component-Resolved Diagnosis to Optimize Allergen-Specific Immunotherapy in the Mediterranean Area. Journal of Investigational Allergology and Clinical Immunology, 2007, 17(1), p. 88–92.

56. WANGORSCH, A., JAMIN, A., LIDHOLM, J., GRÄNI, N., LANG, C., BALLMER-WEBER, B., VIETHS, S., SCHEURER, S. Identification and implication of an allergenic PR-10 protein from walnut in birch pollen associated walnut allergy. Molecular Nutrition and Food Research, 2017, 61, p. 1–9.

57. WEBER, R. Cross-reactivity of pollen allergens: impact on allergen immunotherapy. Annals of Allergy, Asthma and Immunology, 2007, 99(3), p. 203–212.

58. WHO/IUIS Allergen Nomenclature Sub-Committee. Allergen Nomenclature. Allergen.org [online]. [cit. 2019-11-20]. Dostupné na www: http://www.allergen.org/

59. WOJCIECHOWSKA, M., ŻBIKOWSKA-GOTZ, M., MAREK-JÓZEFOWICZ, L., PRZYBYSZEWSKI, M., GOCKI, J., BARTUZI, Z. Allergic phenotypes in adult patients with atopic dermatitis, determined with the ISAC test (ImmunoCAP ISAC). Advances in Dermatology and Allergology, 2018, 35(4), p. 351–359.

60. WOLTHERS, O. D. Component-Resolved Diagnosis in Pediatrics. ISRN Pediatrics, 2012, p. 1–6.

Labels
Dermatology & STDs Paediatric dermatology & STDs
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#