Therapy of the Recurrent Basal Cell Carcinoma by Vismodegib

Czech version

Authors: K. Pizinger; T. Fikrle; B. Divišová; M. Kofroňová
Authors‘ workplace: Dermatovenerologická klinika FN a LF UK Plzeň přednosta prof. MUDr. Karel Pizinger, CSc.
Published in: Čes-slov Derm, 90, 2015, No. 2, p. 56-58
Category: Pharmacologyand Therapy, Clinical Trials

Overview

Vismodegib is a low-molecular inhibitor of hedhe-hog signaling pathway that regulates cell growth. Its activation in adults leads to formation of some tumours, especially, basal cell carcinoma. Authors describe a case of 75-year old patient with unsuccessfully treated advanced, recurrent and inoperable basal cell carcinoma. The tumour healed after six months treatment with vismodegib.

Key words:
basal cell cacinoma – successful treatment with vismodegib

Sources

1. ALI, F. R., LEAR, J. T. Systemic treatments for basal cell carcinoma (BCC): the advent of dermato-oncology in BCC. Br. J. Dermatol., 2013, 169, p. 53–57.

2. ALLY, M. S., YANG, J. Y., JOSEPH, T., THOMPSON, B. et al. The use of vismodegib to shrink keratocystic odontogenic tumors in patients with basal cell nevus syndrome. JAMA, 2014, 150, 5, p. 542–545.

3. CHANG, A. L. S., SOLOMON, A. J., HAINSWORTH, J. D., GOLDBERG, L. et al. Expanded access study of patiens with advanced basal cell carcinoma treated with the hedgehog pathway inhibitor, vismodegib. J. Am. Acad. Dermatol., 2014, 70, p. 60–69.

4. LEAR, J. T. Oral Hedgehog-pathway inhibitors for basal cell carcinoma. N. Engl. J. Med., 2012, 366, p. 2225–2226.

5. REYES-HABITO, C. M., ROH, E. K. Cutaneous reaction to chemotherapeutic drugs and targeted therapies for cancer. J. Am. Acad. Dermatol., 2014, 71, p. 217–227.

6. SEKULIC, A., MIGDEN, M. R., ORO, A. E., DIRIX, L. et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N. Engl. J. Med., 2012, 366, p. 2171–2179.

7. US FOOD and DRUG ADMINISTRATION WEB SITE. Vismodegib. Dostupné na www: http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/

Labels

Dermatology & STDs Paediatric dermatology & STDs

Cutaneous and Mucosal Candidoses

Penile Lymphoedema in Association with Inflammatory Bowel Disease

Frontal Loss of Hair and Eyebrows

Small Melanomas

Article was published in

Czech-Slovak Dermatology

2015 Issue 2