Pigmented Naevi and Their Relationship to Malignant Melanoma
Authors:
S. Pavel; K. Pizinger
Authors‘ workplace:
přednosta prof. MUDr. Karel Pizinger, CSc.
; Dermatolovenerologická klinika LF UK a FN Plzeň
Published in:
Čes-slov Derm, 86, 2011, No. 6, p. 263-271
Category:
Reviews (Continuing Medical Education)
Overview
The development of a higher number of pigmented naevi is an important risk factor for melanoma. This is especially true for larger, so-called clinically atypical or dysplastic naevi. These naevi develop more frequently in people with a fair skin phototype. In the case of congenital naevi the melanoma risk is directly proportional to their size. For the development of the acquired naevi genetic factors appear to play more important role than the sun exposure. The exposure to sunlight can, however, result in the increasing number of naevi. According to various studies the protection with sunscreens is insufficient and, conversely, can lead to development of higher number of naevi. Relatively large number of naevocellular naevi can be often seen in patients with melanoma. Also the members of some families with familiar melanoma may develop increased number of (dysplastic) naevi. The evidence of familiar occurrence of melanoma is important for the identification of genetic factors which may play role in the melanoma initiation. Histopathologic evaluation of pigmented naevi belongs to the most complicated assessments in dermatopathology. The criteria used for lesions evaluation are not entirely specific and that is why some diagnostically relevant changes can be found in both benign and malignant lesions. It is, therefore, necessary to asses the all available data and to consider their mutual importance. The prevention of melanoma is of enormous importance and should particularly involve the patients with high numbers of pigmented, especially dysplastic naevi, patients with large congenital naevi, patients from the families with familiar melanoma and those who already had melanoma. This preventive care should be performed systematically by dermatologists.
Key words:
Pigmented naevi – melanoma – pigmentation – UV radiation
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Dermatology & STDs Paediatric dermatology & STDsArticle was published in
Czech-Slovak Dermatology
2011 Issue 6
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