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Methods and techniques of fertility preservation in patients with endometriosis


Authors: I. Sisková;  L. Mekiňová;  R. Hudeček;  M Ješeta;  S. Šimová
Authors‘ workplace: Gynekologicko-porodnická klinika LF MU a FN Brno
Published in: Ceska Gynekol 2023; 88(6): 454-458
Category:

Overview

: Objective: Endometriosis is a chronic disease with a relatively high prevalence in the female population. Both the disease itself and its surgical treatment can adversely affect the fertility of patients. For this reason, endometriosis is offered as a possible indication for fertility preservation by cryopreservation methods. The aim of this paper is to present the current knowledge on the options of fertility preservation in this subpopulation. Methods: Search of relevant literature in PubMed/Medline, Web of Science and Scopus databases. Results: Fertility preservation by cryopreservation methods has so far been used mainly in the care of women with cancer. With increasing experience, the effectiveness and availability of these methods have increased significantly and the indication spectrum has been extended to selected benign diseases such as endometriosis. Three techniques are currently established in practice: embryo cryopreservation, oocyte cryopreservation and ovarian tissue cryopreservation. Oocyte cryopreservation is the most commonly used technique, since it is the most advantageous for the patient and, according to the available data, is an effective way to increase the chances of future pregnancy for patients with endometriosis The purpose is to realize the protection of reproduction before the planned operation. Conclusion: The diagnosis of endometriosis negatively affects the fertility of women. For some patients, the solution is fertility preservation by cryopreservation methods. Further clinical studies are needed to define exact, practically applicable indication criteria, potential risks of procedures and their benefits and cost-effectiveness.

Keywords:

Endometriosis – fertility preservation – oocyte cryopreservation – embryo cryopreservation – ovarian tissue cryopreservation


Sources

1. Burney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertil Steril 2012; 98 (3): 511–519. doi: 1016/j.fertnstert. 2012.06.029.

2. Moradi Y, Shams-Beyranvand M, Khateri S et al. A systematic review on the prevalence of endometriosis in women. Indian J Med Res 2021; 154 (3): 446–454. doi: 10.4103/ijmr.IJMR_817_18.

3. Meuleman C, Vandenabeele B, Fieuws S et al. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil Steril 2009; 92 (1): 68–74. doi: 10.1016/j.fertnstert.2008.04.056.

4. Bulletti C, Coccia ME, Battistoni S et al. Endometriosis and infertility. J Assist Reprod Genet 2010; 27 (8): 441–417. doi: 10.1007/s10815- 010-9436-1.

5. Bafort C, Beebeejaun Y, Tomassetti C et al. Laparoscopic surgery for endometriosis. Cochrane Database of Systematic Reviews 2020; 10 (10): CD011031. doi: 10.1002/14651858.CD011031.pub3.

6. Alborzi S, Keramati P, Younesi M et al. The impact of laparoscopic cystectomy on ovarian reserve in patients with unilateral and bilateral endometriomas. Fertil Steril 2014; 101 (2): 427–434. doi: 10.1016/j.fertnstert.2013.10.019.

7. Nickkho-Amiry M, Savant R, Majumder K et al. The effect of surgical management of endometrioma on the IVF/ICSI outcomes when compared with no treatment? A systematic review and meta-analysis. Arch Gynecol Obstet 2018; 297 (4): 1043–1057. doi: 10.1007/s00 404-017-4640-1.

8. Smolarz B, Szyłło K, Romanowicz H. Endometriosis: epidemiology, classification, pathogenesis, treatment and genetics (review of literature). Int J Mol Sci 2021; 22 (19): 10554. doi: 10.3390/ijms221910554.

9. Tanbo T, Fedorcsak P. Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options. Acta Obstet Gynecol Scand 2017; 96 (6): 659–667. doi: 10.1111/aogs.13082.

10. Dmowski WP, Rana N, Michalowska J et al. The effect of endometriosis, its stage and activity, and of autoantibodies on in vitro fertilization and embryo transfer success rates. Fertil Steril 1995; 63 (3): 555–562. doi: 10.1016/s0015-028 2 (16) 57425-1.

11. Pellicer A, Valbuena D, Bauset C et al. The follicular endocrine environment in stimulated cycles of women with endometriosis: steroid levels and embryo quality. Fertil Steril 1998; 69 (6): 1135–1141. doi: 10.1016/s0015-0282 (98) 00085-5.

12. Kitajima M, Dolmans MM, Donnez O et al. Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas. Fertil Steril 2014; 101 (4): 1031–1037. doi: 10.1016/ j.fertn stert.2013.12.049.

13. Stilley JA, Birt JA, Sharpe-Timms KL. Cellular and molecular basis for endometriosis-associated infertility. Cell Tissue Res 2012; 349 (3): 849–862. doi: 10.1007/s00441-011-1309-0.

14. Carrillo L, Seidman DS, Cittadini E et al. The role of fertility preservation in patients with endometriosis. J Assist Reprod Genet 2016; 33 (3): 317–323. doi: 10.1007/s10815-016-0646-z.

15. Garcia-Velasco JA, Somigliana E. Management of endometriomas in women requiring IVF: to touch or not to touch. Hum Reprod 2009; 24 (3): 496–501. doi: 10.1093/humrep/den398.

16. Ulrich U, Buchweitz O, Greb R et al. National German guideline (S2k): guideline for the dia g nosis and treatment of endometriosis: long version – AWMF registry no. 015-045. Geburtshilfe Frauenheilkd 2014; 74 (12): 1104–1118. doi: 10.1055/s-0034-1383187.

17. Younis JS, Shapso N, Fleming R et al. Impact of unilateral versus bilateral ovarian endometriotic cystectomy on ovarian reserve: a systematic review and meta-analysis. Hum Reprod Update 2019; 25 (3): 375–391. doi: 10.1093/humupd/dmy049.

18. Benschop L, Farquhar C, van der Poel N et al. Interventions for women with endometrioma prior to assisted reproductive technology. Cochrane Database Syst Rev 2010; (11): CD008571. doi: 10.1002/14651858.CD008571.pub2.

19. ETIC Endometriosis Treatment Italian Club. When more is not better: 10 “don’ts” in endometriosis management. An ETIC * position statement. Hum Reprod Open 2019; 2019 (3): hoz009. doi: 10.1093/hropen/hoz009.

20. Muzii L, Marana R, Angioli R et al. Histologic analysis of specimens from laparoscopic endometrioma excision performed by different surgeons: does the surgeon matter? Fertil Steril 2011; 95 (6): 2116–2119. doi: 10.1016/ j.fertnstert.2011.02.034.

21. Alborzi S, Foroughinia L, Kumar PV et al. A comparison of histopathologic findings of ovarian tissue inadvertently excised with endometrioma and other kinds of benign ovarian cyst in patients undergoing laparoscopy versus laparotomy. Fertil Steril 2009; 92 (6): 2004–2007. doi: 10.1016/j.fertnstert.2008.09.014.

22. Llarena NC, Falcone T, Flyckt RL. Fertility preservation in women with endometriosis. Clin Med Insights Reprod Health 2019; 13: 1179558119873386. doi: 10.1177/11795581 19873386.

23. Dolmans MM, Donnez J. Fertility preservation in women for medical and social reasons: oocytes vs ovarian tissue. Best Pract Res Clin Obstet Gynaecol 2021; 70: 63–80. doi: 10.1016/j.bpobgyn.2020.06.011.

24. Calagna G, Della Corte L, Giampaolino P et al. Endometriosis and strategies of fertility preservation: a systematic review of the literature. Eur J Obstet Gynecol Reprod Biol 2020; 254: 218–225. doi: 10.1016/j.ejogrb.2020.09.045.

25. Bosch E, De Vos M, Humaidan P. The future of cryopreservation in assisted reproductive technologies. Front Endocrinol (Lausanne) 2020; 11: 67. doi: 10.3389/fendo.2020.00067.

26. Practice Committee of the American Society for Reproductive Medicine. Electronic address: asrm@asrm.org. Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion. Fertil Steril 2019; 112 (6): 1022–1033. doi: 10.1016/ j.fertnstert.2019.09.013.

27. Kuroda K, Ikemoto Y, Ochiai A et al. Combination treatment of preoperative embryo cryopreservation and endoscopic surgery (surgery-ART hybrid therapy) in infertile women with diminished ovarian reserve and uterine myomas or ovarian endometriomas. J Minim Invasive Gynecol 2019; 26 (7): 1369–1375. doi: 10.1016/ j.jmig.2019.02.008.

28. EUROSTAT. Statistics. 2023 [online]. Available from: https: //ec.europa.eu/eurostat/data browser/view/DEMO_FIND/bookmark/bar? lang=en&bookmarkId=26565240-1494-4163-bf9c-4bb7215590ff.

29. Cobo A, Giles J, Paolelli S et al. Oocyte vitrification for fertility preservation in women with endometriosis: an observational study. Fertil Steril 2020; 113 (4): 836–844. doi: 10.1016/ j.fertnstert.2019.11.017.

30. Santulli P, Bourdon M, Koutchinsky S et al. Fertility preservation for patients affected by endometriosis should ideally be carried out before surgery. Reprod Biomed Online 2021; 43 (5): 853–863. doi: 10.1016/j.rbmo.2021.08.023.

31. Donnez J, Squifflet J, Dolmans MM et al. Orthotopic transplantation of fresh ovarian cortex: a report of two cases. Fertil Steril 2005; 84 (4): 1018. doi: 10.1016/j.fertnstert.2005.06.011.

32. Fabbri R, Vicenti R, Paradisi R, et al. Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis. Gynecol Endocrinol 2018; 34 (7): 558–562. doi: 10.1080/09513590.2017.1423 468.

33. Becker CM, Bokor A, Heikinheimo O et al. ESHRE guideline: endometriosis. Hum Reprod Open 2022; 2022 (2): hoac009. doi: 10.1093/ hropen/hoac009.

34. Courbiere B, Le Roux E, Mathieu d’Argent E et al. Oocyte vitrification for fertility preservation in women with benign gynecologic dis – ease: national clinical practice guidelines developed by a modified delphi consensus proces. 2021 [online]. Available from: https: //www.preprints.org/manuscript/202107.0125/v1.

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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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Czech Gynaecology

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2023 Issue 6

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