Early pregnancy loss and inherited thrombophilic states

Czech version

Authors: D. Kašparová; Tomáš Fait
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. A. Martan, DrSc.
Published in: Ceska Gynekol 2009; 74(5): 360-365

Overview

Objective:
Review the literature regarding inherited thrombophilic states and early pregnancy loss.

Design:
Literary review.

Setting:
Department of Gynekology and Obstetrics, 1st Faculty of Medicine, Charles University Prague.

Subject and methods:
Thrombotic risk is increased in normal pregnancy. This risk is further enhanced in women with congenital or aquired thrombophilia. As an adequate placental circulation is dependent on the normal balance procoagulant and anticoagulant mechanism, inherited thrombophilia may be associated with fetal loss. Literary review.

Conclusions:
Placental thrombosis may be final common pathophysiologic pathway in most women with habitus abortions and repeated pregnancy wastage. Preliminary nonrandomized studies suggest a benefit for prophylaxis with unfractioned and low-molecular-weight heparin (LMWH), and prospective randomized trials are in progress to define whether LMWH is effective in preventive pregnancy loss and other gestational vascular complications in women with thrombophilia and previus fetal wastage.

Key words:
inherited trombophilia, pregnancy loss, venous thromboembolism, low-molecular-weight heparin.

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