#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Hormonal Suppression and Pubertal Development in Children with Central Precocious Puberty in the First Treatment Cycle 12 Weeks after Injection of Triptoreline 11.25 mg (Diphereline S. R. 11.25 mg): a Pilot Study


Authors: M. Šnajderová 1;  D. Zemková 1;  L. Teslík 2;  M. Pechová 3;  R. Vetešníková-Koubová 4;  H. Mlčochová 4;  J. Vavřinec 1
Authors‘ workplace: Pediatrická klinika 2. LF UK a FN Motol, Praha, přednosta prof. MUDr. J. Vavřinec, DrSc. 1;  Gynekologicko-porodnická klinika 2. LF UK a FN Motol, Praha, přednosta doc. MUDr. L. Rob, CSc. 2;  Ústav klinické biochemie a patobiochemie, FN Motol, Praha, přednosta doc. MUDr. R. Průša, CSc. 3;  Klinika gynekologie dětí a dospívajících 2. LF UK a FN Motol, Praha, přednosta prof. MUDr. J. Hořejší, DrSc. 4
Published in: Ceska Gynekol 2005; 70(2): 107-113
Category: Original Article

Overview

Objective:
To evaluate hormonal suppression and pubertal development in children with central precocious puberty (CPP) after injection of triptoreline 11.25 mg (Diphereline S. R. 11.25 mg; Ipsen) in the first treatment cycle of 12 weeks.

Design:
Pilot study.

Setting:
Paediatric department, University Hospital Motol-Prague.

Methods:
Serum levels of FSHmax and LHmax and basal levels of estradiol/testosterone were monitored in GnRH test before, 4, 8 and 12 weeks after triptoreline 11.25 mg injection in 3 girls and 2 boys with CPP (age 3.9–10.6 years) previously treated by triptoreline 3 mg every 4 weeks. Uterine and ovarian volume, hormonal cytology (vaginal smear), breast development and testicular volume were evaluated before and 12 weeks after triptoreline 11.25 mg injection.

Results:
8 weeks after triptoreline 11.25 mg, FSHmax in girls increased (2.3 IU/l vs. 1.7 IU/l before injection; median) without any other change in 12th week. In boys after initial decrease LHmax 12 weeks after injection rose to 1.7 IU/l (identical as LHmax before injection). Estradiol and testosterone levels were in prepubertal range. Pubertal development in girls did not progress, and testicular volume decreased in both boys (treated for CPP 0.3 and 0.7 years).

Conclusions:
Triptoreline 11.25 mg injection in 12 weeks interval can be considered as effective, useful and safe for therapy of CPP. The long-term follow-up will be necessary.

Key words:
Central precocious puberty, treatment, gonadoliberine analogues, long-acting triptoreline 11.25 mg


Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Czech Gynaecology

Issue 2

2005 Issue 2

Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#