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Congenital Renal Disease in 1961 –2000:Incidence,Prenatal Diagnosis and Prevalence according toMaternal Age


Authors: A. Šípek 1;  V. Gregor 2;  J. Horáček 2;  D. Mašátová 3
Authors‘ workplace: Ústav pro péči o matku a dítě, Praha-Podolí, ředitel doc. MUDr. J. Feyereisl, CSc. 2 Oddělení lékařské genetiky, Fakultní Thomayerova nemocnice, Praha, ředitel ing. J. Pubrdle 3Ústav zdravotnických informací a statisticky České republiky, Praha, ředitelka 1
Published in: Ceska Gynekol 2002; (3): 0
Category:

Overview

Objective:
Presentation of agenesis/hypoplasia of kidneys and cystic kidneys in the Czech Republic during 1961 –2000.Analysis of prevalence of these defects in different groups by maternal age.Design:Retrospective demographic-epidemiological study.Setting:Institute for the Care of Mother and Child,Prague.Method:The author used data from the nationwide register o birth defects in neonates,kept bythe Institute of Health Information and Statistics in the CR during 1990 –2000.Epidemiologicalanalysis of the incidence of agenesis/hypoplasia of the kidneys and cystic kidneys in the CRduring 1961 to 2000 in cases diagnosed prenatally and in born children.The authors made a mathematical-statistical analysis of the prevalence of these defects by maternal age,using the methodof calculation of the 95%confidence interval of probability.Results:In the CR there were during the period from 1961 –2000 1093 registred cases of agenesis/hypoplasia o the kidneys and 1370 cases of cystic kidneys.The mean incidence during theentire period was 1.81 in agenesis/hypoplasia of the kidneys and 2.26 in cystic kidneys per 10 000live born infants.After adding prenatally diagnosed cases and pregnancies terminated on thataccount it was 2.05 a 2.58 per 10 000 live born infants.Conclusion:The investigation of these inborn defects did not confirm nor rule out statisticallya higher risk of women older than the population average.

Key words:
inborn defect,agenesis/hypoplasia of kidneys,cystic kidneys,incidence,Czech Republic,prenatal diagnosis,maternal age

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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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