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Diaphragmatic Hernia in 1961 –2000:Incidence,Prenatal Diagnosis and Prevalence according toMaternal Age


Authors: A. Šípek 1;  V. Gregor 2;  J. Horáček 2;  D. Mašátová 3
Authors‘ workplace: Ústav pro péči o matku a dítě, Praha-Podolí, ředitel doc. MUDr. J. Feyereisl, CSc. 2 Oddělení lékařské genetiky, Fakultní Thomayerova nemocnice, Praha, ředitel ing. J. Pubrdle 3 Ústav zdravotnických informací a statistiky České republiky, Praha, ředitelka 1
Published in: Ceska Gynekol 2002; (3): 0

Overview

Objective:
Presentation of diaphragmatic hernia in the CR in 1961 –2000.Analysis of prevalence ofthese defects in different groups by maternal age.Design:Retrospective demographic-epidemiological study.Setting:Institute for the Care of Mother and Child,Prague.Methods:The authors used data from nationwide registers of birth defects in neonates kept in theInstitute of Health Information and Statistics of the CR during 1995 –2000.Epidemiological analysis o the incidence of diaphragmatic hernia in the CR during 1961 –2000 in newborn infants.Mathematical statistical analysis of prevalence of these defects by maternal age using the methodof 95%confidence interval of probability.Results:In the CR during 1961 –2000 1321 cases of diaphragmatic hernia were recorded.The meanincidence of this defect during the entire period was 2.32 per 10 000 live born infants incl.prenatally diagnosed cases and terminated pregnancies.Including those it was 2.37 per 10 000 liveborn infants.Conclusion:The authors elaborated the mean incidence during the investigation period and inindividual years in born children as well as prenatally diagnosed cases.Also an analysis of theprevalence of these defects by maternal age was made using the method of 95%confidence interval.The authors found a significantly higher risk of development of this defect in foetuses owomen aged 38,42 years or older as compared with the population average.However an unequiwocally increased risk associated with more adwanced age was neither confimed nor ruled out.

Key words:
birth defect,congenital diaphragmatic hernia,incidence,Czech Republic,prenataldiagnosis,maternal age

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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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