Increasing the Effect of Photodynamic Therapy on Basocellular Carcinoma by Synchronic Application of Pulsed Dye Laser
Authors:
M. Vlk; R. Šmucler
Authors‘ workplace:
Stomatologická klinika 1. LF UK a VFN, Centrum fotonické medicíny, Praha
Published in:
Česká stomatologie / Praktické zubní lékařství, ročník 108, 2008, 3, s. 67-71
Overview
For being the most frequent malignity, basocellular carcinoma represents a significant medical, psychological and economic problem, despite its very rare destructive growth and metastases. In particular, success of present therapy of relapsing basaliomas is very low (and decreases to 50%) and it is therefore necessary to search for new methods for increased efficiency with simultaneous esthetic results of treatment (85% of basaliomas are in the head and neck region). Photodynamic therapy is based on activation of a photosensitization agent belongs to most successful possibilities, but fails in up to 4% of primary superficial basaliomas; in nodular and relapsing ones in the generally not recommended. The objective of the study is to improve efficiency of the method by activation of photodynamic therapy by pulsed dye laser, which also exerts a photoselective effect (destroys nutritive vessels). In a study performed in 128 basaliomas with a high proportion of relapsing, laboriously treated ones, a statistically significant high efficiency of activation of aminolevulinic acid with pulsed dye laser has been confirmed as compared with the conventional red light. The efficiency was 89.4% versus 71.9% in favor of the laser.
Key words:
basaliomas - photodynamic therapy - aminolevulinic acid - pulsed dye laser
Sources
1. Nestor, M. S., Gold, M. H., Kauvar, A. N., Taub, A. F., Geronemus, R. G., Ritvo, E. C., Goldman, M. P., Gilbert, D. J., Rochet, D. F., Alster, T. S., Anderson, R. R., Bank, D. E., Carruthers, A., Carruthers, J., Goldberg, D. J., Hanke, C. W., Lowe, N. J., Pariser, D. M., Rigel, D. S., Robins, P., Spenser, J. M., Zelickson, B. D.: The use of photodynamic therapy in dermatology: results of a consensus conference. J. Drugs. Dermatol., 5, 2006, 2, s. 140-154.
2. Fink-Puches, R., Soyer, H. P., Hofer, A., Kerl, H., Wolf, P.: Long-term follow-up and histological changes of superficial nonmelanoma skin cancers treated with topical delta-aminolevulinic acid photodynamic therapy. Arch Dermatol., 134, 1998, 7 s. 821-826.
3. Kennedy, J. C., Pottier, R. H.: Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy. J. Photochem. Photobio. B, 14, 1992, s. 275–292.
4. Calzavara-Pinton, P. G.: Repetitive photodynamic therapy with topical delta-aminolaevulinic acid as an appropriate approach to the routine treatment of superficial non-melanoma skin tumours. J. Photochem. Photobiol. B, 29, 1995, 1, s. 53-57.
5. Pieh, S., Kuchar, A., Novak, P., Kunstfeld, R., Nagel, K., Steinkogler, F. J.: Long term results after surgical basal cell carcinoma excision in the eyelid region. Br. J. Opthalmol, 1999, s. 83-88.
6. Ackroyd, R., Kelty, C., Brown, N., Reed, M.: The History of photodetection and photodynamic therapy. Photochemistry and Photobiology, 74, 2001, 5, s. 656–669.
7. Šmucler, R., Jatšová, E.: Comparative study – aminolevulic acid PDT + Pulsed Dye Laser versus Pulsed Dye Laser alone in treatment of viral warts. Photomedicine and Laser Surgery, 23, 2005, s. 202-205.
8. Šmucler, R., Vlk, M.: Combination of Er:YAG laser and photodynamic therapy in treatment of nodular basal cell carcinoma. Laser Surg. Med., (v tisku-manuscript-LSM-07-0131).
Labels
Maxillofacial surgery Orthodontics Dental medicineArticle was published in
Czech Dental Journal
2008 Issue 3
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