Formulace a technologický vývoj vaginálních globulí s probiotickou aktivitou
Authors:
Zhanna Polova 1; Svitlana Aleinyk 1; Aurelii Kazak 2
Authors‘ workplace:
O. O. Bogomolets National Medical University, Department of Pharmacy and Industrial Technology of Drugs
1; O. O. Bogomolets National Medical University, Department of obstetrics and gynecology № 1, Kiev, Ukraine, City Clinical Hospital № 18
2
Published in:
Čes. slov. Farm., 2020; 69, 90-99
Category:
Original article
Overview
Použití laktobacilů při léčbě a prevenci poruch vaginální mikroflóry, jako je bakteriální vaginóza a vulvovaginální kandidóza, je velmi slibné. Cílem této studie bylo optimalizovat složení a technologii v současné době vyvíjeného léčivého přípravku ІМВ 72-7280 ve formě vaginálních globulí obsahujícího Lactobacillus casei (L. casei).
Parametry kontroly kvality byly definovány v souladu se Státním lékopisem Ukrajiny (2. vydání) a zahrnovaly posouzení vzhledu, stejnoměrnost textury, hmotnostní stejnoměrnost a zkoušku rozpadavosti. Obsah laktobacilů byl hodnocen po přípravě a během doby skladování. V rámci studie bylo vybráno vhodné složení a technologie pro přípravu vaginálních globulí s očekávanou skladovací dobou 6 měsíců. Výsledky popsané studie budou použity pro vývoj technologických instrukcí pro extemporózní vaginální pesary s definovanou probiotickou aktivitou.
Klíčová slova:
vaginální globule – Lactobacilli – vaginální dysbióza
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2020 Issue 2
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