Velikostně redukované mikročástice na bázi Eudragitu® RS připravené metodou odpaření rozpouštědla – sledování vlivu vybraných proměnných na testované parametry
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Kalliopi Vasileiou; Jakub Vysloužil; Miroslava Pavelková; Jan Vysloužil; Kateřina Kubová
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Čes. slov. Farm., 2017; 66, 274-280
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Original Articles
Mikročástice se sníženou velikostí částic byly úspěšně připraveny metodou odpařování rozpouštědla. Pro přípravu každého vzorku byly použity různé parametry a byl hodnocen jejich vliv na výsledné mikročástice. Jako modelové léčivo byl pro enkapsulaci do částic na bázi Eudragit® RS vybrán nerozpustný ibuprofen. Získané mikročástice byly zhodnoceny pomocí optické mikroskopie a skenovací elektronové mikroskopie. Byl sledován vliv objemu vodné fáze (600, 400, 200 ml) a koncentrace polyvinyl alkoholu (1% a 0,1%) na vlastnosti mikročástic, jako je enkapsulační účinnost, drug loading, burst effect a morfologie mikročástic. Bylo zjištěno, že vzorek připravený s 600 ml vodné fáze a 1% koncentrací PVA poskytoval nejpříznivější výsledky.
Klíčová slova:
mikročástice • odpaření rozpouštědla • prodloužené uvolňování léčiva • Eudragit RS®
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Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2017 Issue 6
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