#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

A Study of the Properties of Compacts from a Mixed Dry Binder on the Base of α-Lactose Monohydrate and Microcrystalline Cellulose


Authors: J. Mužíková;  L. Páleník
Authors‘ workplace: Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické technologie
Published in: Čes. slov. Farm., 2005; 54, 118-122
Category: Original Articles

Overview

The paper studies the tensile strength and disintegration time of compacts from the mixed dry binder Microce-Lac®100. Tensile strength and disintegration time of tablets were tested in connection with the following factors: compression force, compression rate, addition of magnesium stearate, addition of ascorbic acid, the model active principle. The compression forces employed were 5, 6, and 7 kN, compression rates, 20 and 40 mm/min, stearate concentration 0, 0.4, and 0.8%, ascorbic acid concentration, 25 and 50%. With increasing addition of the stearate, the strength of compacts from MicroceLacu100 was decreased for both compression rates, but with a higher rate, in a concentration of 0.4%, the decrease in strength was more marked. Disintegration time was increased with compression force and the addition of the stearate, but in all cases it was very short. Increased addition of ascorbic acid further intensified the decrease in the strength of compacts and decreased the disintegration time and the effect of the stearate on it. Disintegration time of compacts with ascorbic acid in a concentration of 50% did not increase with compression force.

Key words:
MicroceLac®100 – magnesium stearate – ascorbic acid – tensile strength of tablets – disinte gration time


Labels
Pharmacy Clinical pharmacology

Article was published in

Czech and Slovak Pharmacy

Issue 3

2005 Issue 3

Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#