Ricin – A Plant Toxin with Possible Therapeutic Use

Czech version

Authors: M. Nagy
Authors‘ workplace: Katedra farmakognózie a botaniky Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in: Čes. slov. Farm., 2004; , 131-134
Category:

Overview

Ricin is a very toxic RIP II type lectin.As no effective antidote is known, its toxicity could be misusedin terrorist actions. The mechanism of the toxic action is currently studied for the preparation ofselective immunotoxins, which could be used in the therapy of various cancer diseases or HIVinfection. There are promising in vitro results, but some adverse in vivo effects limit the use of thesepreparations in real therapy.

Key words:
ricin – Ricinus communis – toxin – monoclonal antibody

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Article was published in

Czech and Slovak Pharmacy

2004 Issue 3