Mycophenolate Mofetil, a New Prospective Immunosuppressant
Authors:
J. Weberová; R. Vobořil 1; V. Semecký
Authors‘ workplace:
Katedra biologických a lékařských věd Farmaceutické fakulty Univerzity Karlovy, Hradec Králové 1 Chirurgická klinika Lékařské fakulty Univerzity Karlovy, Hradec Králové
Published in:
Čes. slov. Farm., 2002; , 220-225
Category:
Overview
The mycophenolate mofetil, a prodrug of mycophenolic acid, is a new immunosuppressive drug witha specific mechanism of action consisting in the inhibition of T - and B-lymphocytes proliferation.A series of animal experiments showed efficiency of the mycophenolate mofetil administered inmonotherapy or in combination with other immunosuppressants to prolong the survival of differentallo - and xenotransplanted grafts. In clinical trials, the mycophenolate mofetil, cyclosporine, andsteroids demonstrated high efficacy in the prevention of acute rejection in the solid allotransplantedorgans. The mycophenolate mofetil seems to be a suitable candidate for the treatment of many other,e.g. autoimmune and inflammatory diseases.
Key words:
mycophenolate mofetil – mycophenolic acid – transplantation – acute rejection –immunosuppression
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2002 Issue 5
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