Immunopathogenesis of Psoriasis and Its Current Therapy Possibilities

Overview

Psoriasis is a partly inflammatory hyperproliferative skin disease. Its origin has not been clarifiedyet, but numerous immunologic, bioregulatory, and biochemical changes accompanying this diseaseare known.Many cell types and a number of immunity systemfactors forming a perfectly interlinkednetwork are involved in the immunity processes in the psoriasis-affected skin. This network isa common place where antipsoriatics operate. There is no therapeutic means known which guaranteespermanent elimination of psoriasis symptoms. External as well as internal therapeutic methodshaving effect on the pathogenetic processes at various levels are combined. UV radiation treatment(SUP), sometimes combined with psoralens (PUVA), tar, and dithranol are some of the classicalmethods of psoriasis treatment. Topical medicamentous treatment with corticoids, vitamin Dderivatives, salicylic acid, urea, and tar plays an important part here.

Key words:
psoriasis – immunology – pathogenesis – therapy – drugs