Treatment Regimens of Neovascular Form of Age-Related Macular Degeneration. A Review
Authors:
Zlatica Fellner 1,2; Nora Majtánová 1,2; Petr Kolář 1,2; Petra Krišková 1; Petra Kéri 1
Authors‘ workplace:
Očná klinika Slovenskej zdravotníckej univerzity a Univerzitnej nemocnice Bratislava
1; Lekárska fakulta, Slovenská zdravotnícka univerzita, Bratislava
2
Published in:
Čes. a slov. Oftal., 80, 2024, No. Ahead of print, p. 1-7
Category:
Review Article
doi:
https://doi.org/10.31348/2024/25
Overview
This article presents an overview of treatment regimens of drugs containing antivascular endothelial growth factor for the treatment of neovascular
form of age-related macular degeneration. Currently, drugs containing antivascular endothelial growth factor are the only effective treatment for this chronic and progressive disease. The treatment regimens for this disease in the last two decades have seen a shift from a simple endeavor to stabilize the disease to achieving maximum improvement of visual acuity and its maintenance, with improvement of the patient's quality of life and a minimal treatment burden on patients and their families. Other goals of the alternative dosing regimens that have replaced the original fixed regimens were greater individualization of the dosing regimen, better patient cooperation, saving financial costs and reducing the burden on application centers. Age-related macular degeneration, whether dry form or wet form, represents a serious health and socioeconomic problem, as the disease is one of the most common causes of severe and irreversible central visual acuity disorders up to the degree of practical blindness of one or both eyes in people over 50 years of age in developed industrialized countries. The most important issue is to ensure early diagnosis of this disease, followed by prompt and continuous treatment with an individualized proactive treatment regimen, with the aim of stabilizing and improving anatomical and functional results.
Keywords:
vascular endothelial growth factor – treatment regimens – antivascular endothelial growth factors – neovascular age-related macular degeneration
Sources
- Moon BH, Kim Y, Kim SY. Twenty years of anti-vascular endothelial growth factor therapeutics in neovascular age-related macular degeneration treatment. Int J Mol Sci.2023 Aug;24(16):13004. doi. org/10.3390/ijms241613004
- Campa C, Costagliola C, Incorvaia C, et al. Inflammatory ediators and angiogenic factors in choroidal neovascularization: pathogenetic interactions and therapeutic implications. Mediators Inflamm. 2010 Aug;2010. pii: 546826. doi. org/10.1155/2010/546826
- Stěpanov A, Studnicka J. Použití anti-VEGF léku v oftalmologii. Klin Farmakol Farm. 2019;33(1):19-24. Czech. doi:10.36290/ far.2019.032
- Heloterä H, Kaarniranta K. A Linkage between Angiogenesis and Inflammation in Neovascular Age-Related Macular Degeneration. Cells. 2022;11(21):3453. doi.org/10.3390/cells11213453
- Kaiser SM, Arepalli S, Ehlers JP. Current and future anti-VEGF agents for neovascular age-related macular degeneration. J Exp Pharmacol. 2021;13:905-912. doi:10.2147/JEP.S259298
- Gualino V, Tadayoni R, Cohen SY, et al. Optical coherence tomography, fluorescein angiography, and diagnosis of choroidal neovascularization in age-related macular degeneration. Retina. 2019 Sep;39(9):1664-1671. doi:10.1097/IAE.0000000000002220
- Told R, Sacu S, Hecht A, et al. Comparison of SD-Optical coherence tomography angiography and indocyanine green angiography in Type 1 and 2 Neovascular Age-related Macular Degeneration. IOVS. 2018 May;59(6):2393-2400. doi:10.1167/iovs.17-22902
- Rocholz R, Corvi F, Weichsel J, Schmid S, Strarenghi G. High resolution imaging in microscopy and ophthalmology: New frontiers in biomedical optics [Internet]. Cham (Switzerland): Springer; 2019. Chapter 6, OCT Angiography (OCTA) in retinal diagnostics; p. 135-160. doi:10.1007/978-3-030-16638-0
- Deng Y, Qiao L, Du M, et al. Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy. Genes Dis. 2021 Feb;9(1):62-79. doi:10.1016/j.gendis.2021.02.009
- Stahl A. The diagnosis and treatment of age-related macular degeneration. Dtsch Arztebl Int. 2020 Jul;117(29-30):513-520. doi:10.3238/ arztebl.2020.0513
- Hang A, Feldman S, Amin AP, et al. Intravitreal anti-vascular endothelial growth factor therapies for retinal disorders. Pharmaceuticals. 2023;16(8):1140. doi:10.3390/ph16081140
- Luu KT, Seal J, Green M, Winskill C, Attar M. Effect of Anti‐VEGF therapy on the disease progression of neovascular age‐related macular degeneration: A systematic review and model‐based meta‐ analysis. J Clin Pharmacol. 2022 May;62(5):594-608. doi:10.1002/ jcph.2002
- Song D, Liu P, Shang K, et al. Application and mechanism of anti-VEGF drugs in age-related macular degeneration. Fron Bioeng Biotechnol.2020;10:943915. doi:10.3389/fbioe.2022.943915
- Hariprasad SM, Gale RP, Weng ChY, et al. An Introduction to Biosimilars for the Treatment of Retinal Diseases: A Narrative Review. Ophthalmol Ther. 2022;11:959-982. doi.:10.1007/s40123-02200488-w
- Gragoudas ES, Adamis AP, Cunningham JR, et al. Pegaptanib for neovascular age-related macular degeneration. N Engl J Med. 2004;351:2805-2816.
- Gonzales CR. Enhanced efficacy associated with early treatment of neovascular age-related macular degeneration with pegaptanib sodium: an exploratory analysis. Retina. 2005;25:815-827.
- Plyukhova AA, Budzinskaya MV, Starostin KM, et al. Comparative safety of bevacizumab, ranibizumab, and aflibercept for treatment of neovascular age-related macular degeneration (AMD): A systematic review and network meta-analysis of direct comparative studies. J.Clin.Med. 2020;9(5):1522. doi:10.3390/jcm9051522
- DeCroos FCh, Reed D, Adam MK, et al. Treat-and-extend therapy using aflibercept for neovascular age-related macular degeneration: a prospective clinical trial. Am J Ophthalmol. 2017;180:142-150. doi:10.1016/j.ajo.2017.06.002
- Nguyen QD, Das A, Do DV, et al. Brolucizumab: evolution through preclinical and clinical studies and the implications for the management of neovascular age-related macular degeneration. Ophthalmology. 2020;127(7):963-976. doi:10.1016/j.ophtha.2019.12.031
- Baumal CR, Spaide RF, Vajzovic L, et al. Retinal vasculitis and intraocular inflammation after intravitreal injection of brolucizumab. Ophthalmology. 2020;127(10):1345-1359. doi:10.1016/j.ophtha.2020.04.017
- Khanani AM, Guymer RH, Basu, et al. TENAYA and LUCERNE: Rationale and Design for the Phase 3 Clinical Trials of Faricimab for Neovascular Age-Related Macular Degeneration. Ophthalmol Sci. 2021 Nov;1(4):100076. doi:10.1016/j.xops.2021.100076
- Liberski S, Wichrowska M, Kocięcki J. Aflibercept versus Faricimab in the treatment of neovascular age-Related macular degeneration and diabetic macular edema: A Review. Int J Mol Sci. 2022 Aug;23(16):9424. doi:10.3390/ijms23169424
- Estarreja J, Mendes P, Silva C, Camacho P, Mateus V. The efficacy, safety, and efficiency of the off-Label use of bevacizumab in patients diagnosed with age-related macular degeneration: Protocol for a systematic review and meta-analysis. JMIR Res Protoc.2023; 12: e38658. doi:10.2196/3858
- Khanna S, Komati R, Eichenbaum DA, et al. Current and upcoming anti-VEGF therapies and dosing strategies for the treatment of neovascular AMD: a comparative review. BMJ Open Ophthalmol. 2019;4(1):e000398. doi:10.1136/bmjophth-2019-000398
- Horner F, Lip PL, Mohammed BR, et al. Comparing effectiveness of three different anti-VEGF treatment regimens for neovascular age-related macular degeneration: two years’ real-world clinical outcomes. Clin Ophthalmol. 2021 Apr;23(15):1703-1713. doi:10.2147/OPTH.S305141
- Gemenetzi M, Patel PJ. A Systematic review of the treat and extend treatment regimen with anti-VEGF agents for neovascular age-Related macular degeneration. Ophthalmol Ther. 2017;6:79-92. doi:10.1007/s40123-017-0087-5
- Patel PJ, Villavicencio P, Hanumunthadu D. Systematic review of neovascular age-related macular degeneration disease activity criteria use to shorten, maintain or extend treatment intervals with anti-VEGF in clinical trials: implications for clinical practice. Ophthalmol Ther. 2023;12:2323-2346. doi:10.1007/s40123-02300768-z
- Abdin AD, Mohamed A, Munteanu C, et al. Intravitreal aflibercept following treat and extend protocol versus fixed protocol for treatment of neovascular age-related macular degeneration. Int J Retina Vitreous.2021;7:74. doi:10.1186/s40942-021-00349-x
- Rosenberg D, Deonarain DM, Gould J, et al. Efficacy, safety, and treatment burden of treat-and-extend versus alternative anti-VEGF regimens for nAMD: a systematic review and meta-analysis. Eye. 2022 Apr;37(1):6-16. doi:10.1038/s41433-022-02020-7
- https://health.gov.sk › Zdroje › Oftlamologia-Liecba-vlhkej-formy-vekom-podmienenej-degeneracie-makuly-anti-VEGF-liek mi-prostr-rezimu-Treat-and-Extend
Labels
OphthalmologyArticle was published in
Czech and Slovak Ophthalmology
![Issue Ahead of print](https://www.prolekare.cz/media/cache/resolve/journal_issue/media/image_pdf/2974d92dee7ee13d85feff0a40634184.jpg)
2024 Issue Ahead of print
Most read in this issue
- Analysis of 50 Most Cited Articles About Refractive Surgery From an Altmetric Perspective
- Leiomyoma – Ciliary Body Tumor. A Case Report
- Intravitreal Dexamethasone Implant in the Treatment of Diabetic Macular Edema Focusing
- Scleral Grafts in Ophthalmic Surgery. A Review