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Current dia­gnostics of secondary progressive form of multiple sclerosis and its treatment with siponimod


Authors: P. Štourač
Authors‘ workplace: Neurologická klinika LF MU a FN Brno
Published in: Cesk Slov Neurol N 2020; 83/116(4): 364-367
Category: Review Article
doi: https://doi.org/10.14735/amcsnn2020364

Overview

Multiple sclerosis is a chronic inflammatory disease of the CNS. Secondary progressive MS is the second most common form of MS worldwide and symptomatic treatment is currently the only available option in the Czech Republic. Neurodegeneration and less inflammatory processes are the main pathophysiological processes underlying the transition to the secondary progressive phase of MS. Because of clinical dia­gnostic obstacles, the dia­gnosis of secondary progressive MS is often postponed by 3 years. Dia­gnostic criteria based on the data from MSBase registry enable the elimination of this dia­gnostic gap. Siponimod is the first oral drug for the treatment of secondary progressive MS with clinical or MRI activity reducing the disability progression or selected MRI parameters. The efficacy and safety of siponimod were tested in the phase III clinical trial EXPAND. The most suitable criteria for treatment with siponimod and its safety profile including possibilities in the case of treatment failure are under scrutiny of the scientific neurological society in the Czech Republic.

Keywords:

diagnosis – treatment – secondary progressive multiple sclerosis – siponimod


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Labels
Paediatric neurology Neurosurgery Neurology

Article was published in

Czech and Slovak Neurology and Neurosurgery

Issue 4

2020 Issue 4

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