Přehled nejdůležitějších metod léčby keratocystického odontogenního tumoru

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Authors: Azadi Mehdi ¹; Bashar Saeed ²; Hajiani Narges ¹; Amiri Hooman ¹; Azadi Sepehr ³; Ansari Zahra ⁴
Authors‘ workplace: Resident of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tehran University of Medical sciences, Tehran, Iran ¹; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Golestan University of Medical Sciences, Gorgan, Iran ²; Dentistry Student, Faculty of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran ³; Doctor of Dental Surgery (DDS), DMD, Tehran, Iran ⁴
Published in: Klin Onkol 2022; 35(1): 10-19
Category: Reviews
doi: https://doi.org/10.48095/ccko202210

Overview

Východiska: Keratocystický odontogenní tumor (keratocystic odontogenic tumor – KCOT) je rekurentní benigní tumor tvaru keratinizovaného epitelu. Způsob léčby je stále předmětem diskusí. Cílem všech léčebných metod je eradikace cysty a omezení rekurence a pooperačních komplikací. Tento přehledový článek byl vytvořen s cílem zhodnotit závěry studií zaměřených na diagnostiku, léčbu a rekurenci KCOT. Metody: Informace byly shromažďovány po zadání slov management, léčba, farmakologie, operace a keratocystický odontogenní tumor do mezinárodních databází Web of Science, PubMed a Scopus. Sledování dat probíhalo v období let 2010–2020. Výsledky: Mezi techniky používané při léčbě patří dekomprese, marsupializace, enukleace s následnou operací čelistní dutiny ze zevního přístupu dle Caldwell-Luca nebo bez ní a resekce. Ze 40 studií byla rekurence pozorována v 13 studiích a u různých léčebných metod se pohybovala v rozmezí 0–48 %. Závěr: V důsledku vysoké rekurence onemocnění se po léčbě doporučuje dlouhodobé sledování. Rozhodnutí o způsobu léčby by mělo zohledňovat věk pacienta, velikost nádoru a místo výskytu, aby se co nejvíce snížila ekonomická a psychická zátěž tímto onemocněním.

Klíčová slova:

léčba – operace – farmakologie – management – keratocystický odontogenní tumor

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