IgG4-releated disease

Czech version

Authors: Z. Adam ¹; Z. Adamová ²; Z. Řehák ³; R. Koukalová ³
Authors‘ workplace: Interní hematologická a onkologická klinika LF MU FN Brno ¹; Chirurgické oddělení, Vsetínská nemocnice a. s. ²; Oddělení nukleární medicíny, MOU Brno ³
Published in: Klin Onkol 2021; 34(2): 92-102
Category: Review
doi: https://doi.org/10.48095/ccko202192

Overview

Background: IgG4-related disease (IgG4-RD) is a non-malignant, chronic, immune-related disease. It was first recognized as a distinct disease in 2012 and the first classification criteria were published in 2020. This new entity can cause fibroinflammatory lesions in nearly any organ. It often presents as a multi-organ disease and can be confused with malignancy, infection or other immune-mediated conditions. Although the disease could affect virtually any organ, there are strong predilections for certain organs: the major salivary glands, the orbits and lacrimal glands, the pancreas and biliary tree, the lungs, the kidneys, the aorta and retroperitoneum, the meninges and the thyroid gland. Purpose: Correlation among clinical, serologic, radiologic and pathologic data is required for establishing IgG4-RD. We sum up the newest information necessary for the diagnosis.

Keywords:

IgG4 – Castleman disease – Eosinophilia – pancreatic tumor

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