#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Occurrence of two histopathologically different malignancies


Authors: J. Tokarčík 1;  D. Slížová 2;  I. Andrašina 3;  D. Šafčák 3;  M. Rudnay 4;  K. Demková 1
Authors‘ workplace: IV. interná klinika LF UPJŠ a UN L. Pasteura V Košiciach 1;  Ústav anatómie, LF UK v Hradci Králové 2;  Klinika rádioterapie a onkológie, VOÚ v Košiciach 3;  Oddelenie rádiodia gnostiky a zobrazovacích metód, UN L. Pasteura a LF UPJŠ v Košiciach 4
Published in: Klin Onkol 2021; 34(2): 147-150
Category: Case Report
doi: https://doi.org/10.48095/ccko2021147

Overview

Background: Synchronous primary malignancies are defined as two or more malignancies without finding a subordinate relationship in different organs of the patient. Reports of patients with primary malignancies with hepatocellular carcinoma are rare. Case: We describe the course of the disease in a 71-year-old patient with a synchronous occurrence of two histopathologically different malignancies. Conclusion: Consistent screening can detect individual tumors early. Understanding the clinicopathological properties and prognostic factors in synchronous malignancies is important to facilitate the treatment.

Keywords:

hepatocellular carcinoma – synchronous malignancies – prostatic carcinoma – sorafenib


Sources

1. Billroth T. Klinik Chirurgische Wien. Erfahrungen auf dem Gebiet der Practischen Chirurgie. Hirschwald Berlin: 1879. Nebst einem Gesammt-Bericht über die chirurgischen Kliniken in Zürich und Wien während der Jahre 1860–1876. [online]. Erreichbar aus: https: //www.zvab.com/Chirurgische-Klinik-Wien-1871-1876-Nebst-Gesammt-Bericht/21658616078/bd.

2. Hu NC, Hsieh SC, Chen TJ et al. Multiple primary malignancies including colon, stomach, lung, breast, and liver cancer: a case report and literature review. Chin Med J 2009; 122: 3091–3093.

3. Bray F, Ferlay JM, Soerjomataram I. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68: 394–424. doi: 10.3322/caac.21492.

4. Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology 2011; 53 (2): 1020–1022. doi: 10.1002/hep.24199.

5. Boyle P, Ferlay J. Cancer incidence and mortality in Europe 2004. Ann Oncol 2005; 16 (3): 481–488. doi: 10.1093/annonc/mdi098.

6. Nordenstedt H, White DL, El-Serag HB. The changing pattern of epidemiology in hepatocellular carcinoma. Dig Liver Dis 2010; 42 (Suppl 3): S206–S214. doi: 10.1016/S1590-8658 (10) 60507-5.

7. Schlabe S, Rockstroh JK. Advances in the treatment of HIV/HCV coinfection in adults. Expert Opin Pharmacother 2018; 19 (1): 49–64. doi: 10.1080/14656566.2017.1419185.

8. Ayuso C, Rimola J, Vilana R et al. Dia­gnosis and staging of hepatocellular carcinoma (HCC): current guidelines. Eur J Radiol 2018; 101: 72–81. doi: 10.1016/j.ejrad.2018.01.025.

9. Pritzová E, Hrnčár M. Pokračujúca liečba hepatocelulárneho karcinómu sorafenibom po rádiologickej progresii ochorenia – kazuistika. [online]. Dostupné z: https: //www.solen.sk/storage/file/article/b057ae29ab530e71d4f4b6c214cfb01b.pdf.

10. Otsuka T, Eguchi Y, Kawazoe S et al. Skin toxicities and survival in advanced hepatocellular carcinoma patients treated with sorafenib. Hepatol Res 2012; 42: 879–886. doi: 10.1111/j.1872-034X.2012.00991.x.

11. Jemal A, Siegel R, Ward E et al. Cancer statistics, 2008. Ca Cancer J Clin 2008; 58 (2): 71–96. doi: 10.3322/CA.2007.0010.

12. Steinberg G, Carter B, Beaty T et al. Family history and the risk of prostate cancer. [online]. Available from: https: //onlinelibrary.wiley.com/doi/epdf/10.1002/pros.2990170409.

13. Carter B, Beaty T, Steinberg G et al. Mendelian inheritance of familial prostate cancer. Proc Natl Acad Sci USA 1992; 89 (8): 3367–3371. doi: 10.1073/pnas.89.8.3367.

14. Gronberg D, Damber L, Damber J. Familial prostate cancer in Sweden. A nationwide register cohort study. Cancer 1996; 77 (1): 138–143. doi: 10.1002/ (SICI) 1097-0142 (19960101) 77: 1<138:: AID-CNCR23>3.0.CO; 2-5.

15. Irimie AP, Achimas-Cadariu P, Burz C et al. Multiple primary malignancies – epidemiological analysis at a single tertiary institution. J Gastrointestin Liver Dis 2010; 19 (1): 69–73.

16. Lin AY, Lu T, Gomez SL. Synchronous cancers: an analysis of SEER registry from 1973 to 2003. [online]. Available from: https: //ascopubs.org/doi/10.1200/jco.2010.28.15_suppl.e12018.

17. American Cancer Society. Cancer Facts & Figures 2018. [online]. Available from: https: //www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2018/cancer-facts-and-figures-2018.pdf.

18. Vogt A, Schmid S, Heinimann K et al. Multiple primary tumours: challenges and approaches, a review. [online]. Available from: https: //www.sciencedirect.com/science/article/pii/S2059702920324510.

19. American Cancer Society. Fakty o rakovine a čísla 2009. [online]. Dostupné z: https: //www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2009.html.

Labels
Paediatric clinical oncology Surgery Clinical oncology

Article was published in

Clinical Oncology

Issue 2

2021 Issue 2

Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#