Immunotherapy of Urothelial Carcinoma of the Bladder – from BCG Vaccines to Targeted Therapy

Czech version

Authors: M. Matoušková
Authors‘ workplace: Urocentrum Praha
Published in: Klin Onkol 2015; 28(Supplementum 4): 95-102
Category: Specials
doi: https://doi.org/10.14735/amko20154S95

Overview

Bladder cancer has high prevalence in men and women. Bladder cancer usually originates from urothelium. More than 75% of cases are classified as non‑muscle‑ invasive bladder cancer. Urothelial bladder carcinoma is usually managed by transurethral resection of the bladder tumor. Role of transurethral resection of the bladder tumor is also essential in bladder cancer staging. Local prophylaxis is used in non‑muscle‑ invasive bladder cancer to reduce risk of recurrence. While local chemoprophylaxis is sufficient in low and middle risk patients, intravesical instillation of Mycobacterium bovis bacillus Calmette‑Guerin (BCG) is preferred in high risk bladder cancer. Chemotherapy alone or in combination with locoregional treatment is used in advanced bladder cancer. New immunotherapy modalities have proven their efficacy in several clinical studies in advanced bladder cancer.

Key words:
urothelial bladder cancer – immunotherapy – BCG vaccine – checkpoint inhibitor

The author declares she has no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.

Submitted:
3. 9. 2015

Accepted:
23. 10. 2015

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