Value of Narrow Band Imaging Endoscopy in Detection of Early Laryngeal Squamous Cell Carcinoma

Czech version

Authors: L. Staníková ¹; H. Kučová ¹; R. Walderová ¹; Karol Zeleník ^1,2; Jana Šatanková ³; Pavel Komínek ^1,2
Authors‘ workplace: Otorinolaryngologická klinika LF OU a FN Ostrava ¹; Katedra kraniofaciálních oborů, LF, Ostravská univerzita v Ostravě ²; Klinika otorinolaryngologie a chirurgie hlavy a krku LF UK a FN Hradec Králové ³
Published in: Klin Onkol 2015; 28(2): 116-120
Category: Original Articles
doi: https://doi.org/10.14735/amko2015116

Overview

Background:
Narrow band imaging (NBI) is an endoscopic method using filtered wavelengths in detection of microvascular abnormalities associated with preneoplastic and neoplastic changes of the mucosa. The aim of the study is to evaluate the value of NBI endoscopy in the diagnosis of laryngeal precancerous and early stages of cancerous lesions and to investigate impact of NBI method in ’prehistological’ diagnostics in vivo.

Materials and Methods:
One hundred patients were enrolled in the study and their larynx was investigated using white light HD endoscopy and narrow band imaging between 6/ 2013– 10/ 2014. Indication criteria included chronic laryngitis, hoarseness for more than three weeks or macroscopic laryngeal lesion. Features of mucosal lesions were evaluated by white light endoscopy and afterwards were compared with intraepithelial papillary capillary loop changes, viewed using NBI endoscopy. Suspicious lesions (leukoplakia, exophytic tumors, recurrent respiratory papillomatosis and/ or malignant type of vascular network by NBI endoscopy) were evaluated by histological analysis, results were compared with ‘prehistological’ NBI diagnosis.

Results:
Using NBI endoscopy, larger demarcation of pathological mucosal features than in white light visualization were recorded in 32/ 100 (32.0%) lesions, in 4/ 100 (4.0%) cases even new lesions were detected only by NBI endoscopy. 63/ 100 (63.0%) suspected lesions were evaluated histologically – malign changes (carcinoma in situ or invasive carcinoma) were observed in 25/ 63 (39.7%). ’Prehistological’ diagnostics of malignant lesions using NBI endoscopy were in agreement with results of histological examination in 23/ 25 (92.0%) cases. The sensitivity of NBI in detecting malignant lesions was 89.3%, specificity of this method was 94.9%.

Conclusion:
NBI endoscopy is a promising optical technique enabling in vivo differentiation of superficial neoplastic lesions. These results suggest endoscopic NBI may be useful in the early detection of laryngeal cancer and precancerous lesions.

Key words:
laryngeal squamous cell carcinoma – narrow band imaging – endoscopy – flexible laryngoscopy

This study was supported by MH CZ – DRO – FNOs/2012.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
19. 1. 2015

Accepted:
27. 1. 2015

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