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Antibody structure and its reactivity.


Authors: P. Štern
Authors‘ workplace: Mimoňská 637/16, 190 00 Praha
Published in: Klin. Biochem. Metab., 24, 2016, No. 1, p. 4-9

Overview

The educational publication describes the antibody structure, various fragments, three-dimensional fixation of domains, the function of disulfide bridges, β-strands and hypervariable loops. It also deals with differences between individual immunoglobulins and their isotypes. The antigen-antibody reaction is interpreted in the aspect of complementarity of reactants, as well as various binding forces participating in the energy of the immunochemical bond. Differences between the antibody bond to immunogen or to hapten and characteristics supporting the immunogenicity of antigen are given as well. Both the relation between the affinity and specifity of immunochemical reaction and the reactivity of naive and mature antibodies are demonstrated.

Keywords:
affinity, antibody, antigen, immunoglobulins, specificity.


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