Antiphospholipid syndrome – diagnostics, manifestation and treatment

Czech version

Authors: H. Ciferská
Authors‘ workplace: Revmatologický ústav a Revmatologická klinika 1. LF UK, Praha
Published in: Kardiol Rev Int Med 2014, 16(5): 410-413
Category: Internal Medicine

Overview

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by various potentially serious and life‑ threatening manifestations. APS occurs in a primary form with no associated conditions, or in a secondary form associated with various other illnesses (autoimmune, neoplastic and others). APS is diagnosed according to clinical and laboratory criteria. It is characterized by recurrent arterial or venous thrombosis and/ or pregnancy‑related complications and laboratory findings of antiphospholipid antibodies in a minimum time interval of 12 weeks between individual laboratory tests. Clinical manifestations of APS can vary and a multidisciplinary approach is needed. Catastrophic APS is a very serious and life‑ threatening condition associated with high mortality and morbidity, although it is rare. An early diagnosis with proper therapy has a serious impact on the prognosis of patients with APS.

Keywords:
antiphospholipid syndrome – systemic lupus erythematosus

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