#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Does ischemic heart disease differ in men and women?


Authors: prof. MUDr. Ján Murín, CSc. 1;  MUDr. Peter Kyčina 2;  MUDr. Alexander Klabník 3
Authors‘ workplace: I. interná klinika, LF UK a FNsP Bratislava 1;  Interné oddelenie, NsP Liptovský Mikuláš 2;  Interné oddelenie, NsP Bánovce n/Bebravou 3
Published in: Kardiol Rev Int Med 2010, 12(3): 110-114

Overview

Many published articles have suggested that differences exist between both sexes with respect to cardiovascular disease and ischemic heart disease, specifically concerning epidemiology of cardiovascular events, etiopathogenesis, diagnostic approaches, treatment and prognosis. These papers confirm that ischemic heart disease in women is not a benign di­sease. Consequently, we should change our clinical attitude and ensure timely diagnosis and appropriate treatment to improve prognosis of women with ischemic heart disease.

Keywords:
ischemic heart disease in women – pathogenesis – risk factors – symptoms – diagnosis – treatment and prognosis


Sources

1. Centers for Disease Control and Prevention (CDC). State-Specific Mortality from Sudden Cardiac Death-United States, 1999. MMWR Morb Mortal Wkly Rep 2002; 51:123–126.

2. Ford ES, Capewell S. Coronary heart disease mortality among young adults in the U.S. from 1980 through 2002: concealed leveling of mortality rates. J Am Coll Cardiol 2007; 50: 2128–2132.

3. Rosamond W, Flegal K, Furie K et al. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics – 2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008; 117: e25–e146.

4. von Mering GO, Arant CB, Wessel TR et al. National Heart, Lung, and Blood Institute. Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women’s Ischemia Syndrome Evaluation (WISE). Circulation 2004; 109: 722–725.

5. Shaw LJ, Shaw RE, Merz CN et al. American College of Cardiology-National Cardiovascular Data Registry Investigators. Impact of ethnicity and gender differences on angiographic coronary artery disease prevalence and in-hospital mortality in the American College of Cardiology-National Cardiovascular Data Registry (ACC-NCDR). Circulation 2008; 117: 1787–1801.

6. Murphy SL. Death: final data for 1998. Natl Vital Stat Rep 2000; 48: 1–105.

7. Ni H, Coady S, Rosamond W et al. Trends from 1987 to 2004 in sudden death due to coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. Am Heart J 2009; 157: 46–52.

8. Olson MB, Kelsey SF, Matthews K et al. Symptoms, myocardial ischaemia and quality of life in women: results from the NHLBI-sponsored WISE Study. Eur Heart J 2003; 24: 1506–1552.

9. Shaw LJ, Merz CN, Pepine CJ et al. Women‘s Ischemia Syndrome Evaluation (WISE) Investigators. The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health/National Heart, Lung, and Blood Institute-Sponsored Women’s Ischemia Syndrome Evalutaion (WISE). Circulation 2006; 114: 894–904.

10. Mokdad AH, Ford ES, Bowman BA et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 2003; 289: 76–79.

11. Spencer EA, Pirie KL, Stevens RJ et al. Million Women Study. Diabetes and modifiable risk factors for cardiovascular disease: the prospective Million Women Study. Eur J Epidemiol 2008; 23: 793–799.

12. Gregg EW, Gu Q, Cheng YJ et al. Mortality trends in men and women with diabetes, 1971 to 2000. Ann Intern Med 2007; 147: 149–155.

13. Daviglus ML, Stamler J, Pirzada A et al. Favorable cardiovascular risk profile in young women and long-term risk of cardiovascular and all-cause mortality. JAMA 2004; 292: 1588–1592.

14. Wong ND, Pio J, Valencia R et al. Distribution of C-reactive protein and its relation to risk factors and coronary heart disease risk estimation in the National Health and Nutrition Examination Survey (NHANES) III. Prev Cardiol 2001; 4: 109–114.

15. Zethelius B, Berglund L, Sundstrom J et al. Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. N Engl J Med 2008; 358: 2107–2116.

16. Bairey Merz CN, Johnson BD, Sharaf BL et al. WISE Study Group. Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: a report from the NHLBI-sponsored WISE study. J Am Coll Cardiol 2003; 41: 413–419.

17. Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones & risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 2006; 295: 1288–1299.

18. Ankle Brachial Index Collaboration. Fowkes FG, Murray GD, Butcher I et al. Ankle brachial index combined with Framingham risk score to predict cardiovascular events and mortality: a meta-analysis. JAMA 2008; 300: 197–208.

19. Simon A, Chironi G, Levinson J. Comparative performance of subclinical atherosclerosis tests in predicting coronary heart disease in asymptomatic individuals. Eur Heart J 2007; 28: 2967–2671.

20. Nasir K, Raggi P, Rumberger JA et al. Coronary artery calcium volume scores on electron beam tomography in 12,936 asymptomatic adults. Am J Cardiol 2004; 93: 1146–1149.

21. O’Keefe-McCarthy S. Women’s experiences of cardiac pain: a review of the literature. Can J Cardiovasc Nurs 2008; 18: 18–25.

22. Robinson JG, Wallace R, Limacher M et al. Cardio­vascular risk in women with non-specific chest pain (from the Women’s Health Initiative Hormone Trials). Am J Cardiol 2008; 102: 693–699.

23. Gulati M, Cooper-DeHoff RM, McClure C et al. Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: a report from The National Institutes of Health-National Heart, Lung, and Blood Insstitute-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) study and the St James Women Take Heart (WTH) project. Arch Intern Med 2009; 169: 843–850.

24. Kwook YS, Kim C, Grady D et al. Meta-analysis of exercise testing to detect coronary artery disease in women. Am J Cardiol 1999; 83: 660–666.

25. Mieres JH, Shaw LJ, Arai A et al. Cardiac Imaging Committee, Council on Clinical Cardiology, and the Cardiovascular Imaging and Intervention Committee, Council on Cardiovascular Radiology and Intervention, American Heart Association. Role of noninvasive testing in the clinical evaluation of women with suspected coronary artery disease: Consensus statement from the Cardiac Imaging Committee, Council on Clinical Cardiology, and the Cardiovascular Imaging and Intervention Committee, Council on Cardiovascular Radiology and Intervention, American Heart Association. Circulation 2005; 111: 682–696.

26. Shaw LJ, Olson MB, Kip K et al. The value of estimated functional capacity in estimating outcome: results from the NHLBI-sponsored women’s ischemia syndrome evaluation (WISE) study. J Am Coll Cardiol 2006; 47: S36–S43.

27. Wessel TR, Arant CB, Olson MB et al. Relationship of physical fitness vs body mass index with coronary artery disease and cardiovascular events in women. JAMA 2004; 292: 1179–1187.

28. Shaw LJ, Iskandrian AE. Prognostic value of stress gated SPECT in patients with known or suspected coronary artery disease. J Nucl Cardiol 2004; 11: 171–185.

29. Pundziute G, Schuijf JD, Jukema JW et al. Gender influence on the diagnostic accuracy of 64-slice multislice computed tomography coronary angiography for detection of obstructive coronary artery disease. Heart 2008; 94: 48–52.

30. Sekhri N, Timmis A, Chen R et al. Inequity of access to investigation and effect on clinical outcomes: prognostic study of coronary angiography for suspected stable angina pectoris. BMJ 2008; 336: 1058–1061.

31. Anderson RD, Pepine CJ. Gender differences in the treatment of acute myocardial infarction: bias or biology? Circulation 2007; 115: 823–826.

32. Hibino H, Kurachi Y. A new insight into the pathogenesis of coronary vasospasm. Circ Res 2006; 98: 579–581.

33. Burke AP, Kolodgie F, Farb A et al. Gender differences in coronary plaque morphology in sudden coronary death. Circulation 2003; 108: IV165.

34. Wong TY, Klein R, Sharrett AR et al. Retinal arteriolar narrowing and risk of coronary heart disease in men and women. JAMA 2002; 287: 1153–1159.

35. Rossi R, Nuzzo A, Origliani G et al. Prognostic role of flow-mediated dilation and cardiac risk factors in post-menopausal women. J Am Coll Cardiol 2008; 51: 997–1002.

36. Lerman A, Zeiher AM. Endothelial function: cardiac events. Circulation 2005; 111: 363–368.

37. Modena MG, Bonetti L, Coppi F et al. Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women. J Am Coll Cardiol 2002; 40: 505–510.

38. LJ Shaw, R Bugiardini, CNB Merz. Women and Ischemic Heart Disease: Evolving Knowledge. J Am Coll Cardiol 2009; 54: 1561–1575.

39. Vaccarino V, Parsons L, Every NR et al. Sex-based differences in early mortality after myocardial infarction. National Registry of Myocardial Infarction 2 Participants. N Enl J Med 1999; 341: 217–225.

40. Antman EM, Morrow DA, McCabe Ch et al. ExTract-TIMI 25 Investigators. Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction. N Engl J Med 2006; 354: 1477–1488.

41. Diver DJ, Bier JD, Ferreira PE et al. Clinical and arteriographic characterization of patients with unstable angina without critical coronary arterial narrowing (from the TIMI-IIIA trial). Am J Cardiol 1994; 74: 531–537.

42. Bugiardini R, Manfrini O, Pizzi C et al. Endothelial function predicts future development of coronary artery disease. A study on women with chest pain and normal angiograms. Circulation 200; 109: 2518–2523.

43. O’Donoghue M, Boden WE, Braunwald E et al. Early invasive vs conservative treatment strategies in women and men with unstable angina and non-ST-segment elevation myocardial infarction: a meta-analysis. JAMA 2008; 300: 71–80.

44. Lansky AJ. Outcomes of percutaneous and surgical revascularization in women. Prog Cardiovas Dis 2004; 46: 305–319.

45. Blomkalns AL, Chen AY, Hochman JS et al. CRUSADE Investigators. Gender disparities in the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: large-scale observations from the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the American College of Cardiology/American Heart Association Guidelines) National Quality Improvement Initiative. J Am Coll Cardiol 2005; 45: 832–837.

46. Novack V, Cutlip DE, Jotkowitz A et al. Reduction in sex-based mortality difference with implementation of new cardiology guidelines. Am J Med 2008; 121: 597–603.

47. Gan SC, Beaver SK, Houck PM et al. Treatment of acute myocardial infarction and 30-day mortality among women and men. N Engl J Med 2000; 343: 8–15.

48. Daly C, Clements F, Lopez Sendon JL et al. Euro Heart Survey Investigators. Gender differences in the management and clinical outcome of stable angina. Circulation 2006; 113: 490–498.

49. Murin J. Kardiovaskulárne ochorenia u žien. Pohľad na stabilnú anginu pektoris. Kardiologie pro prax 2008; 3: 20–23.

50. Sutsch G, Oechslin E, Mayer I et al. Effect of diltiazem on coronary flow reserve in patients with microvascular angina. Int J Cardiol 1995; 52: 135–1343.

51. Lanza GA, Colonna G, Pasceri V et al. Atenolol versus amlodipine versus isosorbide-5-mononitrate on anginal symptoms in syndrome X. Am J Cardiol 1999; 84: 854–856.

52. Pizzi C, Manfrini O, Fontana F et al. Angiotensin-converting enzyme inhibitors and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cardiac Syndrome X: role of superpoxide dismutase activity. Circulation 2004; 109: 53–58.

53. Kayikcioglu M, Payzin S, Yavuzgil O et al. Benefits of statin treatment in cardiac syndrome-X. Eur Heart J 2003; 24: 1999–2005.

54. Lerman A, Burnett JC jr, Higano ST et al. Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation 1998; 97: 2123–2128.

55. Adamson DL, Webb M, Collins P. Esterified estrogens combined with methyltestosterone improve emotional well-being in postmenopausal women with chest pain and normal coronary angiograms. Menopause 2001; 8: 233–238.

Labels
Paediatric cardiology Internal medicine Cardiac surgery Cardiology
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#