#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

What have imaging studies with evolocumab yielded?


Authors: Tomáš Kovárník 1;  Karel Kopřiva 2;  Jan Pudil 1;  Zhi Chen 3;  Milan Šonka 3
Authors‘ workplace: II. interní klinika kardiologie a angiologie 1. LF UK a VFN v Praze 1;  Kardiologie (KAR), Nemocnice Na Homolce, Praha 2;  Dept. of Electrical & Computer Engineering and Iowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA, USA 3
Published in: AtheroRev 2022; 7(3): 159-165
Category: Clinical Studies

Overview

This review describes usual endpoints in trials assessing changes of atherosclerotic plaques during lipid-lowering therapy. Authors focus their attention to the trials using evolocumab as an active drug.

Keywords:

optical coherence tomography – evolocumab – atherosclerosis regression – intravascular ultrasound


Sources

1. Oyama K, Furtado R, Fagundes A et al. Effect of Evolocumab on Complex Coronary Requiring Revascularization. J Am Coll Cardiol 2021; 77(3): 259–267. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jacc.2020.11.011>.

2. Sabatine M, Giugliano R, Keech A et al. Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med 2017; 376(18): 1713–1722. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1615664>.

3. Nicholls SJ, Hsu A, Wolski K et al. Intravascular ultrasound-derived measures of coronary atherosclerotic plaque burden and clinical outcome. J Am Coll Cardiol 2010; 55(21): 2399–2407. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jacc.2010.02.026>.

4. Bhindi R, Guan M, Zhao Y et al. Coronary atheroma regression and adverse cardiac events: a systematic review and meta-regression analysis. Atherosclerosis 2019; 284: 194–201. Dostupné z DOI: <http://dx.doi.org/10.1016/j.atherosclerosis.2019.03.005>.

5. Mintz GS, Garcia-Gracia HM, Nicholls SJ et al. Clinical expert consensus document on standards for acquisition, measurement and reporting of intravascular ultrasound regression/progression studies. Eurointervention 2011; 6(9): 1123–1130. Dostupné z DOI: <http://dx.doi.org/10.4244/EIJV6I9A195>.

6. Nicholls S, Puri R, Anderson T et al. Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial. JAMA 2016; 316(22): 2373–2384. Dostupné z DOI: <http://dx.doi.org/10.1001/jama.2016.16951>.

7. Kovárník T, Kopřiva K, Pudil J. Regrese koronární aterosklerózy a možnosti jejího zobrazení se zaměřením na výsledky studie GLAGOV. [Examination methods for coronary atherosclerosis regression with special focus on GLAGOV trial]. Vnitř Lék 2018; 64(1): 61–64.

8. Hougaard M, Hansen HS, Thayssen P et al. Influence of ezetimibe in addition to high-dose atorvastatin therapy on plaque composition in patients with ST-segment elevation myocardial infarction assessed by serial intravascular ultrasound with iMap: the OCTIVUS trial. Cardiovasc Revasc Med 2017; 18: 110–117. Dostupné z DOI: <http://dx.doi.org/10.1016/j.carrev.2016.11.010>.

9. Nozue T, Yamamoto S, Tohyama S et al. Statin treatment for coronary artery plaque composition based on intravascular ultrasound radiofrequency data analysis. Am Heart J 2012; 163(2): 191–199.e1. Dostupné z DOI: <http://doi 10.1016/j.ahj.2011.11.004>.

10. Lee SWL, Hau WK, Kong SL et al. Virtual histology findings and effects of varying doses of atorvastatin on coronary plaque volume and composition in statin-naive patients – The VENUS study. Circ J 2012; 76(11): 2662–2672. Dostupné z DOI: <http://dx.doi.org/10.1253/circj.cj-12–0325>.

11. Puri R, Libby P, Nissen SE et al. Long-term effects of maximally intensive statin therapy on changes in coronary atheroma composition: insights from SATURN. Eur Heart J Cardiovasc Imaging 2014; 15(4): 380–388. Dostupné z DOI: <http://dx.doi.org/10.1093/ehjci/jet251>.

12. Kovarnik T, Mintz GS, Skalicka H et al. Virtual Histology Evaluation of Atherosclerosis Regression During Atorvastatin and Ezetimibe Administration. Circ J 2012; 76(1):176–183. Dostupné z DOI: <http://dx.doi.org/10.1253/circj.cj-11–0730>.

13. Nair A, Kuban BD, Tuzcu EM et al. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation 2002; 106(17): 2200–2206. Dostupné z DOI: <http://dx.doi.org/10.1161/01.cir.0000035654.18341.5e>.

14. Yano H, Horinaka S, Ishimitsu T. Effect of evolocumab therapy on coronary fibrous cap thickness assessed by optical coherence tomography in patients with acute coronary syndrome. J Cardiol 2020; 75(3): 289–295. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jjcc.2019.08.002>.

15. Kassis N, Kovarnik T, Chen Z et al. Fibrous Cap Thickness Predicts Stable Coronary Plaque Progression: Early Clinical Validation of a Semiautomated OCT Technology. JSCAI (Journal of the Society for Cardiovascular Angiography & Intervention) 2022. In press. Dostupné z DOI: <https://doi.org/10.1016/j.jscai.2022.100400>.

16. Nicholls S, Kataoka Y, Nissen S et al. Effect of Evolocumab on Coronary Plaque Phenotype and Burden in Statin-Treated Patients Following Myocardial Infarction. JACC Cardiovasc Imaging 2022; 15(7): 1308–1321. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jcmg.2022.03.002>.

17. Gao F, Wang ZJ, Ma XT et al. Effect of alirocumab on coronary plaque in patients with coronary artery disease assessed by optical coherence tomography. Lipids Health Dis 2021; 20(1): 106. Dostupné z DOI: <http://dx.doi.org/10.1186/s12944–021–01528–3>.

18. Zanchin Ch, Koskinas K, Ueki Y et al. Effects of the PCSK9 antibody alirocumab on coronary atherosclerosis in patients with acute myocardial infarction: a serial, multivessel, intravascular ultrasound, near-infrared spectroscopy and optical coherence tomography imaging study–Rationale and design of the PACMAN-AMI trial. Am Heart J 2021; 238: 33–44. Dostupné z DOI: <http://dx.doi.org/10.1016/j.ahj.2021.04.006>.

19. Otake H, Sugizaki Y, Toba T et al. Efficacy of alirocumab for reducing plaque vulnerability: Study protocol for ALTAIR, a randomized controlled trial in Japanese patients with coronary artery disease receiving rosuvastatin. J Cardiol 2019; 73(3): 228–232. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jjcc.2018.11.012>.

20. Rioufol G, Finet G, Ginon I et al. Multiple atherosclerotic plaque rupture in acute coronary syndrome a three-vessel intravascular ultrasound study. Circulation 2002; 106(4): 804–808. Dostupné z DOI: <http://dx.doi.org/10.1161/01.cir.0000025609.13806.31>. Retraction in Notice of retraction. Circulation 2012; 125(23): e1019. Dostupné z DOI: <http://dx.doi.org/10.1161/CIR.0b013e31825f643c>.

21. Nicholls S, Tuzcu M, Sipahi I et al. Relationship between atheroma regression and change in lumen size after infusion of Apolipoprotein A-I Milano. J Am Coll Cardiol 2006; 47: 992–997.

22. Arbad-Zadeh A, Fuster V. From detecting the vulnerable plaque to managing the vulnerable patient. JACC 2019; 74(12): 1582–1593. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jacc.2019.07.062>.

Labels
Angiology Diabetology Internal medicine Cardiology General practitioner for adults
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#