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Hypolipidemic treatment and microvascular complications of diabetes

Czech version

Authors: Branislav Vohnout 1,2,3,5;  Jana Lisičanová 3;  Andrea Havranová 4
Authors‘ workplace: Ústav výživy, Fakulta ošetrovateľstva a zdravotníckych odborných štúdií, SZU v Bratislave 1;  Ústav epidemiológie LF UK, Bratislava 2;  Ambulancia diabetológie a porúch látkovej premeny a výživa, Diabeda s. r. o., Bratislava 3;  Ústav klinického a translačného výskumu – Biomedicínske centrum SAV, Bratislava 4;  Koordinačné centrum pre familiárne hyperlipoproteinémie, SZU v Bratislave 5
Published in: AtheroRev 2019; 4(2): 95-99
Category: Reviews

Overview

Diabetes mellitus (DM) is associated with an increased risk of developing micro- and macrovascular complications. One of the factors that may be involved in the onset and progression of microvascular impairment is dyslipidemia. While the effect of dyslipidemia and its treatment on cardiovascular risk in patients is well known, the effect of hypolipidemic treatment on microvascular complications is not so clear. Although some studies suggest a possible effect of statins on some microvascular complications, these data are often contradictory, and the positive effect of statins on microvascular complications has not been demonstrated. On the other hand, the results of clinical trials show the promising effect of fibrates on the progression of microvascular complications of diabetes. Within the FIELD and ACCORD studies, treatment with fenofibrate led to a slowdown in the progression of diabetic retinopathy, and in the FIELD study retinal laser treatment was significantly reduced and the number of non-traumatic lower limb amputations decreased. This positive effect is probably due not only to the hypolipidemic but also to other pleiotropic effects of such treatment. The paper presents an overview of the effects of hypolipidemic treatment with respect to influencing the individual microvascular complications of diabetes.

Keywords:

diabetes – fenofibrate – microvascular complications

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Labels
Angiology Diabetology Internal medicine Cardiology General practitioner for adults
Diabetes mellitus, kardiovaskulární onemocnění a poruchy metabolizmu lipidů
New hypolipidemic agents in the treatment of diabetic dyslipidemia
The role of bilirubin in diabetes, metabolic syndrome and cardiovascular diseases
Hypertension and diabetes – malignant cardiometabolic combination
Effect of novel anti-diabetic medication on cardiovascular risk
ODYSSEY OUTCOMES Study: other clinical relevant analyses
HDL-C and stratification of individual risk
Current medical literature: exploration of facts
22. kongres o ateroskleróze
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