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The Effect of Continuous Veno-venous Hemofiltration on T lymphocytes and Monocytes Activation in Critically Ill Patients in Sepsis


Authors: J. Příhodová 4;  M. Holub 1;  J. Hanzlíková 3;  M. Matějovič 2;  V. Šrámek 2;  I. Novák 2
Authors‘ workplace: 3. klinika infekčních a tropických nemocí 1. LF UK, Praha, přednosta doc. MUDr. A. Lobovská, CSc. 1
Published in: Anest. intenziv. Med., , 2000, č. 6, s. 267-270
Category:

Overview

Elimination methods can improve the prognosis of critically ill patients in sepsis. With respect to that, higher activation of monocytes duringplasmapheresis could possibly play a role (increase of HLA-DR+ monocytes in peripheral blood). We observed a decrease of T lymphocyte activationin 19 patients after 24 hours of continuous veno-venous hemofiltration – CVVH (p < 0,01). On the third day of CVVH this activation returned to thelevels before initiating of the elimination method. Trend of monocyte activation followed the same course; however, it did not reach statisticalsignificance. The observed changes in the activation direct an attention to possible immunomodulatory effects of this elimination method.

Key words:
CVVH – sepsis – HLA-DR – T cells – monocytes – critically ill

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Labels
Anaesthesiology, Resuscitation and Inten Intensive Care Medicine
Topics Journals
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