Ondansetron in the prevention of postoperative nausea and vomiting

Czech version

Authors: P. Kothaj ¹; M. Novotný ²; M. Onderčanin ³; J. Příborský ⁵; J. Vlček ⁶; F. Vyhnánek ⁷
Authors‘ workplace: Chirurgické oddělení nemocnice F. D. Roosevelta, Banská Bystrica 2 ARO, NMP Malvazinky, Praha 5 3 ARO, NsP, Galanta 4 Glaxo Wellcome s. r. o., Praha 9 5 Chirurgická klinika, FN Ostrava-Zábřeh 6 Klinika anesteziologie a resuscitace, FN Olomouc 7 Chirurgick ¹
Published in: Anest. intenziv. Med., , 1998, č. 6, s. 238-240
Category:

Overview

Ondansetron in the prevention of postoperative nausea and vomiting (PONV) in patients with general anaesthesia undergoing elective abdominal surgery was evaluated in randomised, double blind, placebo controlled, multicenter, parallel group study. Based on the results, we can conclude that ondansetron in dose 4 mg i.v. is effective in the prevention of postoperative hausea and vomiting. Number of emetic episodes was in ondansetron group statistically significantly lower and no nausea was observed in larger number of patients. No significant increase of adverse events was observed in ondansetron group vs. placebo.

Key words:
ondansetron – postoperative nausea and vomiting – double blind study

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